Expression and function of T cell homing molecules in Hodgkin's lymphoma. Export

@article{citeulike:5982439, abstract = {Circulating T lymphocytes enter a tissue if they express appropriate chemokine receptors and adhesion molecules to engage ligands presented at this site. To aid rational development of T cell-based therapies for Hodgkin's lymphoma (HL), we have assessed the expression and function of homing receptors on tumour-infiltrating T cells in HL and compared them with T cells from unaffected lymph nodes and colorectal cancer tissue. Chemokine receptors CXCR3, CXCR4 and CCR7 were expressed on a large proportion of T cells within HL tissue and mediated chemotaxis to purified chemokine. The corresponding ligands (CXCL10, CXCL12, CCL21) were expressed on the malignant cells and/or vascular endothelium. Adhesion molecules including CD62L were widely expressed on HL-derived T cells and their corresponding ligands were detected on vessels within the tumour. This homing phenotype was distinct from T cells isolated from colorectal cancer, but matched closely the phenotype of T cells from unaffected lymph nodes. Thus, T cell recruitment to HL resembles entry of na\"{i}ve/central memory T cells into normal lymph nodes. This has important implications for current approaches to treat HL using T cells activated and expanded in vitro that lack CCR7 and CD62L expression.}, author = {Machado, Lee and Jarrett, Ruth and Morgan, Susan and Murray, Paul and Hunter, Beatrix and Hamilton, Emma and Crocker, John and Thomas, Wendy and Steven, Neil and Ismail, Tariq and Chapman, Ann and Adams, David H. and Lee, Steven P.}, citeulike-article-id = {5982439}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s00262-008-0528-z}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18488221}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18488221}, doi = {10.1007/s00262-008-0528-z}, issn = {1432-0851}, journal = {Cancer immunology, immunotherapy : CII}, keywords = {adhesion\_molecules, cancer\_tissue, central\_memory, chemokine, chemokine\_receptors, chemotaxis, colorectal, cxcr4, hodgkin\_s\_lymphoma, ligands, lymph\_nodes, lymphoma, malignant\_cells, phenotype, rational\_development, recruitment, t\_cells, t\_lymphocytes}, month = {January}, number = {1}, pages = {85--94}, posted-at = {2009-10-21 18:43:44}, priority = {2}, title = {Expression and function of T cell homing molecules in Hodgkin's lymphoma.}, url = {http://dx.doi.org/10.1007/s00262-008-0528-z}, volume = {58}, year = {2009} }

TY - JOUR ID - citeulike:5982439 L3 - citeulike-article-id:5982439 N2 - Circulating T lymphocytes enter a tissue if they express appropriate chemokine receptors and adhesion molecules to engage ligands presented at this site. To aid rational development of T cell-based therapies for Hodgkin's lymphoma (HL), we have assessed the expression and function of homing receptors on tumour-infiltrating T cells in HL and compared them with T cells from unaffected lymph nodes and colorectal cancer tissue. Chemokine receptors CXCR3, CXCR4 and CCR7 were expressed on a large proportion of T cells within HL tissue and mediated chemotaxis to purified chemokine. The corresponding ligands (CXCL10, CXCL12, CCL21) were expressed on the malignant cells and/or vascular endothelium. Adhesion molecules including CD62L were widely expressed on HL-derived T cells and their corresponding ligands were detected on vessels within the tumour. This homing phenotype was distinct from T cells isolated from colorectal cancer, but matched closely the phenotype of T cells from unaffected lymph nodes. Thus, T cell recruitment to HL resembles entry of naïve/central memory T cells into normal lymph nodes. This has important implications for current approaches to treat HL using T cells activated and expanded in vitro that lack CCR7 and CD62L expression. IS - 1 JF - Cancer immunology, immunotherapy : CII SN - 1432-0851 EP - 94 TI - Expression and function of T cell homing molecules in Hodgkin's lymphoma. VL - 58 SP - 85 KW - adhesion_molecules KW - cancer_tissue KW - central_memory KW - chemokine KW - chemokine_receptors KW - chemotaxis KW - colorectal KW - cxcr4 KW - hodgkin_s_lymphoma KW - ligands KW - lymph_nodes KW - lymphoma KW - malignant_cells KW - phenotype KW - rational_development KW - recruitment KW - t_cells KW - t_lymphocytes AU - Machado, Lee AU - Jarrett, Ruth AU - Morgan, Susan AU - Murray, Paul AU - Hunter, Beatrix AU - Hamilton, Emma AU - Crocker, John AU - Thomas, Wendy AU - Steven, Neil AU - Ismail, Tariq AU - Chapman, Ann AU - Adams, David AU - Lee, Steven PY - 2009/01// UR - http://dx.doi.org/10.1007/s00262-008-0528-z ER -