Enabling a systems biology approach to immunology: focus on innate immunity. Export

@article{citeulike:4528436, abstract = {Immunity is not simply the product of a series of discrete linear signalling pathways; rather it is comprised of a complex set of integrated responses arising from a dynamic network of thousands of molecules subject to multiple influences. Its behaviour often cannot be explained or predicted solely by examining its components. Here, we review recently developed resources for the systems-level investigation of immunity. Although innate immunity is emphasized here, its considerable overlap with adaptive immunity makes many of these resources relevant to both arms of the immune response. We discuss recent studies implementing these approaches and illustrate the potential of systems biology to generate novel insights into the complexities of innate immunity.}, author = {Gardy, Jennifer L. and Lynn, David J. and Brinkman, Fiona S. and Hancock, Robert E.}, citeulike-article-id = {4528436}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.it.2009.03.009}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1471490609000763}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19428301}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19428301}, day = {08}, doi = {10.1016/j.it.2009.03.009}, issn = {1471-4981}, journal = {Trends in immunology}, keywords = {computer\_science, conceptual\_immunology, innate\_immunity, review, systems\_biology}, month = {June}, number = {6}, pages = {249--262}, posted-at = {2009-05-16 19:24:47}, priority = {4}, title = {Enabling a systems biology approach to immunology: focus on innate immunity.}, url = {http://dx.doi.org/10.1016/j.it.2009.03.009}, volume = {30}, year = {2009} }

TY - JOUR ID - citeulike:4528436 L3 - citeulike-article-id:4528436 N2 - Immunity is not simply the product of a series of discrete linear signalling pathways; rather it is comprised of a complex set of integrated responses arising from a dynamic network of thousands of molecules subject to multiple influences. Its behaviour often cannot be explained or predicted solely by examining its components. Here, we review recently developed resources for the systems-level investigation of immunity. Although innate immunity is emphasized here, its considerable overlap with adaptive immunity makes many of these resources relevant to both arms of the immune response. We discuss recent studies implementing these approaches and illustrate the potential of systems biology to generate novel insights into the complexities of innate immunity. IS - 6 JF - Trends in immunology SN - 1471-4981 EP - 262 TI - Enabling a systems biology approach to immunology: focus on innate immunity. VL - 30 SP - 249 KW - computer_science KW - conceptual_immunology KW - innate_immunity KW - review KW - systems_biology AU - Gardy, Jennifer AU - Lynn, David AU - Brinkman, Fiona AU - Hancock, Robert PY - 2009/06/08/ UR - http://dx.doi.org/10.1016/j.it.2009.03.009 ER -