RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis Export

@article{citeulike:4775456, abstract = {Necrosis can be induced by stimulating death receptors with tumor necrosis factor (TNF) or other agonists; however, the underlying mechanism differentiating necrosis from apoptosis is largely unknown. We identified the protein kinase receptor-interacting protein 3 (RIP3) as a molecular switch between TNF-induced apoptosis and necrosis in NIH 3T3 cells and found that RIP3 was required for necrosis in other cells. RIP3 did not affect RIP1-mediated apoptosis but was required for RIP1-mediated necrosis and the enhancement of necrosis by the caspase inhibitor zVAD. By activating key enzymes of metabolic pathways, RIP3 regulates TNF-induced reactive oxygen species production, which partially accounts for RIP3's ability to promote necrosis. Our data suggest that modulation of energy metabolism in response to death stimuli has an important role in the choice between apoptosis and necrosis. 10.1126/science.1172308}, author = {Zhang, Duan-Wu and Shao, Jing and Lin, Juan and Zhang, Na and Lu, Bao-Ju and Lin, Sheng-Cai and Dong, Meng-Qiu and Han, Jiahuai}, citeulike-article-id = {4775456}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1172308}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/325/5938/332}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19498109}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19498109}, day = {17}, doi = {10.1126/science.1172308}, journal = {Science}, keywords = {apoptosis, energy\_metabolism, necrosis, rip3, tnf\_sf}, month = {July}, number = {5938}, pages = {332--336}, posted-at = {2009-07-23 15:06:42}, priority = {2}, title = {RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis}, url = {http://dx.doi.org/10.1126/science.1172308}, volume = {325}, year = {2009} }

TY - JOUR ID - citeulike:4775456 L3 - citeulike-article-id:4775456 N2 - Necrosis can be induced by stimulating death receptors with tumor necrosis factor (TNF) or other agonists; however, the underlying mechanism differentiating necrosis from apoptosis is largely unknown. We identified the protein kinase receptor-interacting protein 3 (RIP3) as a molecular switch between TNF-induced apoptosis and necrosis in NIH 3T3 cells and found that RIP3 was required for necrosis in other cells. RIP3 did not affect RIP1-mediated apoptosis but was required for RIP1-mediated necrosis and the enhancement of necrosis by the caspase inhibitor zVAD. By activating key enzymes of metabolic pathways, RIP3 regulates TNF-induced reactive oxygen species production, which partially accounts for RIP3's ability to promote necrosis. Our data suggest that modulation of energy metabolism in response to death stimuli has an important role in the choice between apoptosis and necrosis. 10.1126/science.1172308 IS - 5938 JF - Science EP - 336 TI - RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis VL - 325 SP - 332 KW - apoptosis KW - energy_metabolism KW - necrosis KW - rip3 KW - tnf_sf AU - Zhang, Duan-Wu AU - Shao, Jing AU - Lin, Juan AU - Zhang, Na AU - Lu, Bao-Ju AU - Lin, Sheng-Cai AU - Dong, Meng-Qiu AU - Han, Jiahuai PY - 2009/07/17/ UR - http://dx.doi.org/10.1126/science.1172308 ER -