iNKT cell development is orchestrated by different branches of TGF-beta signaling Export

@article{citeulike:4799885, abstract = {Invariant natural killer T (iNKT) cells constitute a distinct subset of T lymphocytes exhibiting important immune-regulatory functions. Although various steps of their differentiation have been well characterized, the factors controlling their development remain poorly documented. Here, we show that TGF-{beta} controls the differentiation program of iNKT cells. We demonstrate that TGF-{beta} signaling carefully and specifically orchestrates several steps of iNKT cell development. In vivo, this multifaceted role of TGF-{beta} involves the concerted action of different pathways of TGF-{beta} signaling. Whereas the Tif-1{gamma} branch controls lineage expansion, the Smad4 branch maintains the maturation stage that is initially repressed by a Tif-1{gamma}/Smad4-independent branch. Thus, these three different branches of TGF-{beta} signaling function in concert as complementary effectors, allowing TGF-{beta} to fine tune the iNKT cell differentiation program. 10.1084/jem.20090127}, author = {Doisne, Jean-Marc and Bartholin, Laurent and Yan, Kai-Ping and Garcia, Celine N. and Duarte, Nadia and Le Luduec, Jean-Benoit and Vincent, David and Cyprian, Farhan and Horvat, Branka and Martel, Sylvie and Rimokh, Ruth and Losson, Regine and Benlagha, Kamel and Marie, Julien C.}, citeulike-article-id = {4799885}, citeulike-linkout-0 = {http://dx.doi.org/10.1084/jem.20090127}, citeulike-linkout-1 = {http://jem.rupress.org/cgi/content/abstract/206/6/1365?etoc}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19451264}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19451264}, day = {8}, doi = {10.1084/jem.20090127}, journal = {J. Exp. Med.}, keywords = {development, differentiation, nkt\_cells, tgf-beta}, month = {June}, number = {6}, pages = {1365--1378}, posted-at = {2009-06-10 18:38:35}, priority = {2}, title = {iNKT cell development is orchestrated by different branches of TGF-{beta} signaling}, url = {http://dx.doi.org/10.1084/jem.20090127}, volume = {206}, year = {2009} }

TY - JOUR ID - citeulike:4799885 L3 - citeulike-article-id:4799885 N2 - Invariant natural killer T (iNKT) cells constitute a distinct subset of T lymphocytes exhibiting important immune-regulatory functions. Although various steps of their differentiation have been well characterized, the factors controlling their development remain poorly documented. Here, we show that TGF-{beta} controls the differentiation program of iNKT cells. We demonstrate that TGF-{beta} signaling carefully and specifically orchestrates several steps of iNKT cell development. In vivo, this multifaceted role of TGF-{beta} involves the concerted action of different pathways of TGF-{beta} signaling. Whereas the Tif-1{gamma} branch controls lineage expansion, the Smad4 branch maintains the maturation stage that is initially repressed by a Tif-1{gamma}/Smad4-independent branch. Thus, these three different branches of TGF-{beta} signaling function in concert as complementary effectors, allowing TGF-{beta} to fine tune the iNKT cell differentiation program. 10.1084/jem.20090127 IS - 6 JF - J. Exp. Med. EP - 1378 TI - iNKT cell development is orchestrated by different branches of TGF-{beta} signaling VL - 206 SP - 1365 KW - development KW - differentiation KW - nkt_cells KW - tgf-beta AU - Doisne, Jean-Marc AU - Bartholin, Laurent AU - Yan, Kai-Ping AU - Garcia, Celine AU - Duarte, Nadia AU - Le Luduec, Jean-Benoit AU - Vincent, David AU - Cyprian, Farhan AU - Horvat, Branka AU - Martel, Sylvie AU - Rimokh, Ruth AU - Losson, Regine AU - Benlagha, Kamel AU - Marie, Julien PY - 2009/06/08/ UR - http://dx.doi.org/10.1084/jem.20090127 ER -