Dynamic Signaling Network for the Specification of Embryonic Pancreas and Liver Progenitors Export

@article{citeulike:5050574, abstract = {Studies of the formation of pancreas and liver progenitors have focused on individual inductive signals and cellular responses. Here, we investigated how bone morphogenetic protein, transforming growth factor-{beta} (TGF{beta}), and fibroblast growth factor signaling pathways converge on the earliest genes that elicit pancreas and liver induction in mouse embryos. The inductive network was found to be dynamic; it changed within hours. Different signals functioned in parallel to induce different early genes, and two permutations of signals induced liver progenitor domains, which revealed flexibility in cell programming. Also, the specification of pancreas and liver progenitors was restricted by the TGF{beta} pathway. These findings may enhance progenitor cell specification from stem cells for biomedical purposes and can help explain incomplete programming in stem cell differentiation protocols. 10.1126/science.1174497}, author = {Wandzioch, Ewa and Zaret, Kenneth S.}, citeulike-article-id = {5050574}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1174497}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/324/5935/1707}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19556507}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19556507}, day = {26}, doi = {10.1126/science.1174497}, journal = {Science}, keywords = {development, differentiation, embryogenesis, liver\_hepatic, pancreas, signaling, stem\_cells, tgf-beta}, month = {June}, number = {5935}, pages = {1707--1710}, posted-at = {2009-07-07 21:00:22}, priority = {2}, title = {Dynamic Signaling Network for the Specification of Embryonic Pancreas and Liver Progenitors}, url = {http://dx.doi.org/10.1126/science.1174497}, volume = {324}, year = {2009} }

TY - JOUR ID - citeulike:5050574 L3 - citeulike-article-id:5050574 N2 - Studies of the formation of pancreas and liver progenitors have focused on individual inductive signals and cellular responses. Here, we investigated how bone morphogenetic protein, transforming growth factor-{beta} (TGF{beta}), and fibroblast growth factor signaling pathways converge on the earliest genes that elicit pancreas and liver induction in mouse embryos. The inductive network was found to be dynamic; it changed within hours. Different signals functioned in parallel to induce different early genes, and two permutations of signals induced liver progenitor domains, which revealed flexibility in cell programming. Also, the specification of pancreas and liver progenitors was restricted by the TGF{beta} pathway. These findings may enhance progenitor cell specification from stem cells for biomedical purposes and can help explain incomplete programming in stem cell differentiation protocols. 10.1126/science.1174497 IS - 5935 JF - Science EP - 1710 TI - Dynamic Signaling Network for the Specification of Embryonic Pancreas and Liver Progenitors VL - 324 SP - 1707 KW - development KW - differentiation KW - embryogenesis KW - liver_hepatic KW - pancreas KW - signaling KW - stem_cells KW - tgf-beta AU - Wandzioch, Ewa AU - Zaret, Kenneth PY - 2009/06/26/ UR - http://dx.doi.org/10.1126/science.1174497 ER -