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The impact of negative selection on thymocyte migration in the medulla Export

Nat Immunol, Vol. 10, No. 8. (21 August 2009), pp. 823-830.

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migration_homimg t_cells thymic_medulla thymic_selection thymus

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Self-reactive thymocytes are eliminated through negative selection in the thymic medulla. Robey and colleagues find that autoreactive thymocytes show slower and more confined migration than that of polyclonal thymocytes in the medulla.


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