Synchronous and Stochastic Patterns of Gene Activation in the Drosophila Embryo Export

@article{citeulike:5252133, abstract = {Drosophila embryogenesis is characterized by rapid transitions in gene activity, whereby crudely distributed gradients of regulatory proteins give way to precise on/off patterns of gene expression. To explore the underlying mechanisms, a partially automated, quantitative in situ hybridization method was used to visualize expression profiles of 14 developmental control genes in hundreds of embryos. These studies revealed two distinct patterns of gene activation: synchronous and stochastic. Synchronous genes display essentially uniform expression of nascent transcripts in all cells of an embryonic tissue, whereas stochastic genes display erratic patterns of de novo activation. RNA polymerase II is "pre-loaded" (stalled) in the promoter regions of synchronous genes, but not stochastic genes. Transcriptional synchrony might ensure the orderly deployment of the complex gene regulatory networks that control embryogenesis. 10.1126/science.1173976}, author = {Boettiger, Alistair N. and Levine, Michael}, citeulike-article-id = {5252133}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1173976}, citeulike-linkout-1 = {http://www.sciencemag.org/content/325/5939/471.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/325/5939/471.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/325/5939/471}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/19628867}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=19628867}, day = {24}, doi = {10.1126/science.1173976}, journal = {Science}, keywords = {drosophila, embryogenesis, gene\_expression, gene\_networks, stochastic\_processes\_modeling}, month = {July}, number = {5939}, pages = {471--473}, posted-at = {2009-07-26 11:32:02}, priority = {2}, title = {Synchronous and Stochastic Patterns of Gene Activation in the Drosophila Embryo}, url = {http://dx.doi.org/10.1126/science.1173976}, volume = {325}, year = {2009} }

TY - JOUR ID - citeulike:5252133 L3 - citeulike-article-id:5252133 N2 - Drosophila embryogenesis is characterized by rapid transitions in gene activity, whereby crudely distributed gradients of regulatory proteins give way to precise on/off patterns of gene expression. To explore the underlying mechanisms, a partially automated, quantitative in situ hybridization method was used to visualize expression profiles of 14 developmental control genes in hundreds of embryos. These studies revealed two distinct patterns of gene activation: synchronous and stochastic. Synchronous genes display essentially uniform expression of nascent transcripts in all cells of an embryonic tissue, whereas stochastic genes display erratic patterns of de novo activation. RNA polymerase II is "pre-loaded" (stalled) in the promoter regions of synchronous genes, but not stochastic genes. Transcriptional synchrony might ensure the orderly deployment of the complex gene regulatory networks that control embryogenesis. 10.1126/science.1173976 IS - 5939 JF - Science EP - 473 TI - Synchronous and Stochastic Patterns of Gene Activation in the Drosophila Embryo VL - 325 SP - 471 KW - drosophila KW - embryogenesis KW - gene_expression KW - gene_networks KW - stochastic_processes_modeling AU - Boettiger, Alistair AU - Levine, Michael PY - 2009/07/24/ UR - http://dx.doi.org/10.1126/science.1173976 ER -