Eos Mediates Foxp3-Dependent Gene Silencing in CD4+ Regulatory T Cells Export

@article{citeulike:5661823, abstract = {CD4+ regulatory T cells (Tregs) maintain immunological self-tolerance and immune homeostasis by suppressing aberrant or excessive immune responses. The core genetic program of Tregs and their ability to suppress pathologic immune responses depends on the transcription factor Foxp3. Despite progress in understanding mechanisms of Foxp3-dependent gene activation, the molecular mechanism of Foxp3-dependent gene repression remains largely unknown. We identified Eos, a zinc-finger transcription factor of the Ikaros family, as a critical mediator of Foxp3-dependent gene silencing in Tregs. Eos interacts directly with Foxp3 and induces chromatin modifications that result in gene silencing in Tregs. Silencing of Eos in Tregs abrogates their ability to suppress immune responses and endows them with partial effector function, thus demonstrating the critical role that Eos plays in Treg programming. 10.1126/science.1176077}, author = {Pan, Fan and Yu, Hong and Dang, Eric V. and Barbi, Joseph and Pan, Xiaoyu and Grosso, Joseph F. and Jinasena, Dinili and Sharma, Sudarshana M. and McCadden, Erin M. and Getnet, Derese and Drake, Charles G. and Liu, Jun O. and Ostrowski, Michael C. and Pardoll, Drew M.}, citeulike-article-id = {5661823}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1176077}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/325/5944/1142}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19696312}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19696312}, day = {28}, doi = {10.1126/science.1176077}, journal = {Science}, keywords = {eos, foxp3, transcription\_factors, treg\_cells}, month = {August}, number = {5944}, pages = {1142--1146}, posted-at = {2009-09-20 16:19:23}, priority = {5}, title = {Eos Mediates Foxp3-Dependent Gene Silencing in CD4+ Regulatory T Cells}, url = {http://dx.doi.org/10.1126/science.1176077}, volume = {325}, year = {2009} }

TY - JOUR ID - citeulike:5661823 L3 - citeulike-article-id:5661823 N2 - CD4+ regulatory T cells (Tregs) maintain immunological self-tolerance and immune homeostasis by suppressing aberrant or excessive immune responses. The core genetic program of Tregs and their ability to suppress pathologic immune responses depends on the transcription factor Foxp3. Despite progress in understanding mechanisms of Foxp3-dependent gene activation, the molecular mechanism of Foxp3-dependent gene repression remains largely unknown. We identified Eos, a zinc-finger transcription factor of the Ikaros family, as a critical mediator of Foxp3-dependent gene silencing in Tregs. Eos interacts directly with Foxp3 and induces chromatin modifications that result in gene silencing in Tregs. Silencing of Eos in Tregs abrogates their ability to suppress immune responses and endows them with partial effector function, thus demonstrating the critical role that Eos plays in Treg programming. 10.1126/science.1176077 IS - 5944 JF - Science EP - 1146 TI - Eos Mediates Foxp3-Dependent Gene Silencing in CD4+ Regulatory T Cells VL - 325 SP - 1142 KW - eos KW - foxp3 KW - transcription_factors KW - treg_cells AU - Pan, Fan AU - Yu, Hong AU - Dang, Eric AU - Barbi, Joseph AU - Pan, Xiaoyu AU - Grosso, Joseph AU - Jinasena, Dinili AU - Sharma, Sudarshana AU - McCadden, Erin AU - Getnet, Derese AU - Drake, Charles AU - Liu, Jun AU - Ostrowski, Michael AU - Pardoll, Drew PY - 2009/08/28/ UR - http://dx.doi.org/10.1126/science.1176077 ER -