Amyloid-beta Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle Export

@article{citeulike:5865106, abstract = {Amyloid-{beta} (A{beta}) accumulation in the brain extracellular space is a hallmark of Alzheimer's disease. The factors regulating this process are only partly understood. A{beta} aggregation is a concentration-dependent process that is likely responsive to changes in brain interstitial fluid (ISF) levels of A{beta}. Using in vivo microdialysis in mice, we found that the amount of ISF A{beta} correlated with wakefulness. The amount of ISF A{beta} also significantly increased during acute sleep deprivation and during orexin infusion, but decreased with infusion of a dual orexin receptor antagonist. Chronic sleep restriction significantly increased, and a dual orexin receptor antagonist decreased, A{beta} plaque formation in amyloid precursor protein transgenic mice. Thus, the sleep-wake cycle and orexin may play a role in the pathogenesis of Alzheimer's disease. 10.1126/science.1180962}, author = {Kang, Jae-Eun and Lim, Miranda M. and Bateman, Randall J. and Lee, James J. and Smyth, Liam P. and Cirrito, John R. and Fujiki, Nobuhiro and Nishino, Seiji and Holtzman, David M.}, citeulike-article-id = {5865106}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1180962}, citeulike-linkout-1 = {http://www.sciencemag.org/content/1180962v1/.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/1180962v1/.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19779148}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19779148}, day = {13}, doi = {10.1126/science.1180962}, journal = {Science}, keywords = {amiloid-beta, circadian\_rhythms, orexin, sleep}, month = {November}, number = {5955}, pages = {1005--1007}, posted-at = {2009-11-13 19:23:55}, priority = {2}, title = {Amyloid-{beta} Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle}, url = {http://dx.doi.org/10.1126/science.1180962}, volume = {326}, year = {2009} }

TY - JOUR ID - citeulike:5865106 L3 - citeulike-article-id:5865106 N2 - Amyloid-{beta} (A{beta}) accumulation in the brain extracellular space is a hallmark of Alzheimer's disease. The factors regulating this process are only partly understood. A{beta} aggregation is a concentration-dependent process that is likely responsive to changes in brain interstitial fluid (ISF) levels of A{beta}. Using in vivo microdialysis in mice, we found that the amount of ISF A{beta} correlated with wakefulness. The amount of ISF A{beta} also significantly increased during acute sleep deprivation and during orexin infusion, but decreased with infusion of a dual orexin receptor antagonist. Chronic sleep restriction significantly increased, and a dual orexin receptor antagonist decreased, A{beta} plaque formation in amyloid precursor protein transgenic mice. Thus, the sleep-wake cycle and orexin may play a role in the pathogenesis of Alzheimer's disease. 10.1126/science.1180962 IS - 5955 JF - Science EP - 1007 TI - Amyloid-{beta} Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle VL - 326 SP - 1005 KW - amiloid-beta KW - circadian_rhythms KW - orexin KW - sleep AU - Kang, Jae-Eun AU - Lim, Miranda AU - Bateman, Randall AU - Lee, James AU - Smyth, Liam AU - Cirrito, John AU - Fujiki, Nobuhiro AU - Nishino, Seiji AU - Holtzman, David PY - 2009/11/13/ UR - http://dx.doi.org/10.1126/science.1180962 ER -