The functional plasticity of T cell subsets Export

@article{citeulike:5913569, abstract = {In 1986, Robert Coffman and Timothy Mossman first described the division of CD4+ T cells into functional subsets, termed T helper 1 (TH1) and TH2, based on cytokine production, and in doing so unwittingly opened a Pandora's box of complexity and controversy. Although the mechanisms that regulate TH1 and TH2 cells are now well known, recent descriptions of other CD4+ T cell subsets — such as regulatory T cells, T follicular helper cells, TH17, TH22 and most recently TH9 and TH22 cells — have questioned how we think of T cell subsets and what commitment to a functional T cell subset means. Here, Nature Reviews Immunology asks four leaders in the field their thoughts on the functional plasticity of T cell subsets.}, author = {Bluestone, Jeffrey A. and Mackay, Charles R. and O'Shea, John J. and Stockinger, Brigitta}, citeulike-article-id = {5913569}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nri2654}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nri2654}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19809471}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19809471}, day = {07}, doi = {10.1038/nri2654}, issn = {1474-1733}, journal = {Nature Reviews Immunology}, keywords = {cell\_lineage, cell\_plasticity, cell\_types, review, t\_cells, t\_helper\_cells, th17\_cells, treg\_cells}, month = {October}, number = {11}, pages = {811--816}, posted-at = {2009-10-23 18:33:42}, priority = {2}, publisher = {Nature Publishing Group}, title = {The functional plasticity of T cell subsets}, url = {http://dx.doi.org/10.1038/nri2654}, volume = {9}, year = {2009} }

TY - JOUR ID - citeulike:5913569 L3 - citeulike-article-id:5913569 N2 - In 1986, Robert Coffman and Timothy Mossman first described the division of CD4+ T cells into functional subsets, termed T helper 1 (TH1) and TH2, based on cytokine production, and in doing so unwittingly opened a Pandora's box of complexity and controversy. Although the mechanisms that regulate TH1 and TH2 cells are now well known, recent descriptions of other CD4+ T cell subsets — such as regulatory T cells, T follicular helper cells, TH17, TH22 and most recently TH9 and TH22 cells — have questioned how we think of T cell subsets and what commitment to a functional T cell subset means. Here, Nature Reviews Immunology asks four leaders in the field their thoughts on the functional plasticity of T cell subsets. IS - 11 JF - Nature Reviews Immunology SN - 1474-1733 EP - 816 TI - The functional plasticity of T cell subsets PB - Nature Publishing Group VL - 9 SP - 811 KW - cell_lineage KW - cell_plasticity KW - cell_types KW - review KW - t_cells KW - t_helper_cells KW - th17_cells KW - treg_cells AU - Bluestone, Jeffrey AU - Mackay, Charles AU - O'Shea, John AU - Stockinger, Brigitta PY - 2009/10/07/ UR - http://dx.doi.org/10.1038/nri2654 ER -