Asymmetric centrosome inheritance maintains neural progenitors in the neocortex Export

@article{citeulike:5941456, abstract = {Asymmetric divisions of radial glia progenitors produce self-renewing radial glia and differentiating cells simultaneously in the ventricular zone (VZ) of the developing neocortex. Whereas differentiating cells leave the VZ to constitute the future neocortex, renewing radial glia progenitors stay in the VZ for subsequent divisions. The differential behaviour of progenitors and their differentiating progeny is essential for neocortical development; however, the mechanisms that ensure these behavioural differences are unclear. Here we show that asymmetric centrosome inheritance regulates the differential behaviour of renewing progenitors and their differentiating progeny in the embryonic mouse neocortex. Centrosome duplication in dividing radial glia progenitors generates a pair of centrosomes with differently aged mother centrioles. During peak phases of neurogenesis, the centrosome retaining the old mother centriole stays in the VZ and is preferentially inherited by radial glia progenitors, whereas the centrosome containing the new mother centriole mostly leaves the VZ and is largely associated with differentiating cells. Removal of ninein, a mature centriole-specific protein, disrupts the asymmetric segregation and inheritance of the centrosome and causes premature depletion of progenitors from the VZ. These results indicate that preferential inheritance of the centrosome with the mature older mother centriole is required for maintaining radial glia progenitors in the developing mammalian neocortex.}, author = {Wang, Xiaoqun and Tsai, Jin-Wu and Imai, Janice H. and Lian, Wei-Nan and Vallee, Richard B. and Shi, Song-Hai}, citeulike-article-id = {5941456}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature08435}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature08435}, day = {15}, doi = {10.1038/nature08435}, issn = {0028-0836}, journal = {Nature}, keywords = {asymmetric\_devision, centrosomes, neural\_stem\_cells, neurogenesis, stem\_cells}, month = {October}, number = {7266}, pages = {947--955}, posted-at = {2009-10-14 21:55:32}, priority = {2}, publisher = {Nature Publishing Group}, title = {Asymmetric centrosome inheritance maintains neural progenitors in the neocortex}, url = {http://dx.doi.org/10.1038/nature08435}, volume = {461}, year = {2009} }

TY - JOUR ID - citeulike:5941456 L3 - citeulike-article-id:5941456 N2 - Asymmetric divisions of radial glia progenitors produce self-renewing radial glia and differentiating cells simultaneously in the ventricular zone (VZ) of the developing neocortex. Whereas differentiating cells leave the VZ to constitute the future neocortex, renewing radial glia progenitors stay in the VZ for subsequent divisions. The differential behaviour of progenitors and their differentiating progeny is essential for neocortical development; however, the mechanisms that ensure these behavioural differences are unclear. Here we show that asymmetric centrosome inheritance regulates the differential behaviour of renewing progenitors and their differentiating progeny in the embryonic mouse neocortex. Centrosome duplication in dividing radial glia progenitors generates a pair of centrosomes with differently aged mother centrioles. During peak phases of neurogenesis, the centrosome retaining the old mother centriole stays in the VZ and is preferentially inherited by radial glia progenitors, whereas the centrosome containing the new mother centriole mostly leaves the VZ and is largely associated with differentiating cells. Removal of ninein, a mature centriole-specific protein, disrupts the asymmetric segregation and inheritance of the centrosome and causes premature depletion of progenitors from the VZ. These results indicate that preferential inheritance of the centrosome with the mature older mother centriole is required for maintaining radial glia progenitors in the developing mammalian neocortex. IS - 7266 JF - Nature SN - 0028-0836 EP - 955 TI - Asymmetric centrosome inheritance maintains neural progenitors in the neocortex PB - Nature Publishing Group VL - 461 SP - 947 KW - asymmetric_devision KW - centrosomes KW - neural_stem_cells KW - neurogenesis KW - stem_cells AU - Wang, Xiaoqun AU - Tsai, Jin-Wu AU - Imai, Janice AU - Lian, Wei-Nan AU - Vallee, Richard AU - Shi, Song-Hai PY - 2009/10/15/ UR - http://dx.doi.org/10.1038/nature08435 ER -