Biased segregation of DNA and centrosomes |[mdash]| moving together or drifting apart? Export

@article{citeulike:5998017, abstract = {Old and newly synthesized centrosomes have different microtubule nucleating abilities and they contribute to cell polarity when they migrate to opposite poles during cell division. The asymmetric localization of epigenetic marks and kinetochore proteins could lead to the differential recognition of sister chromatids and the biased segregation of DNA strands to daughter cells during cell division. We propose that this asymmetric localization is linked to biased chromatid segregation, which might also be related to the acquisition of distinct cell fates after mitosis.}, author = {Tajbakhsh, Shahragim and Gonzalez, Cayetano}, citeulike-article-id = {5998017}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrm2784}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrm2784}, day = {01}, doi = {10.1038/nrm2784}, issn = {1471-0072}, journal = {Nature Reviews Molecular Cell Biology}, keywords = {asymmetric\_devision, centrosomes, review, segregation, stem\_cells}, month = {November}, number = {11}, pages = {804--810}, posted-at = {2009-10-23 15:30:04}, priority = {2}, publisher = {Nature Publishing Group}, title = {Biased segregation of DNA and centrosomes |[mdash]| moving together or drifting apart?}, url = {http://dx.doi.org/10.1038/nrm2784}, volume = {10}, year = {2009} }

TY - JOUR ID - citeulike:5998017 L3 - citeulike-article-id:5998017 N2 - Old and newly synthesized centrosomes have different microtubule nucleating abilities and they contribute to cell polarity when they migrate to opposite poles during cell division. The asymmetric localization of epigenetic marks and kinetochore proteins could lead to the differential recognition of sister chromatids and the biased segregation of DNA strands to daughter cells during cell division. We propose that this asymmetric localization is linked to biased chromatid segregation, which might also be related to the acquisition of distinct cell fates after mitosis. IS - 11 JF - Nature Reviews Molecular Cell Biology SN - 1471-0072 EP - 810 TI - Biased segregation of DNA and centrosomes |[mdash]| moving together or drifting apart? PB - Nature Publishing Group VL - 10 SP - 804 KW - asymmetric_devision KW - centrosomes KW - review KW - segregation KW - stem_cells AU - Tajbakhsh, Shahragim AU - Gonzalez, Cayetano PY - 2009/11/01/ UR - http://dx.doi.org/10.1038/nrm2784 ER -