leliavski's Akiba [1 article]

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RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis.

Journal of immunology (Baltimore, Md. : 1950), Vol. 182, No. 10. (15 May 2009), pp. 6079-6087.

by T. Totsuka, T. Kanai, Y. Nemoto, et al.T. Tomita, R. Okamoto, K. Tsuchiya, T. Nakamura, N. Sakamoto, H. Akiba, K. Okumura, H. Yagita, M. Watanabe

posted to autoimmune_diseases chronic_colitis foxp3 inflammatory_bowel_diseases rank-rankl-opg t_cells treg_cells by leliavski on 2009-05-10 10:48:49

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Abstract

It is now clear that functional CD4(+)CD25(+) regulatory T (T(R)) cells exist as part of the normal immune population and prevent the development of intestinal inflammation. We have recently shown that CD4(+)CD25(+) T(R) cells reside in the intestine and control intestinal homeostasis in humans and mice. In this study, we demonstrate that the TNF family molecule RANKL and its receptor RANK are critically involved in controlling the function of CD4(+)CD25(+) T(R) cells in the intestine. We first found that RANKL was ...

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leliavski's Akiba [1 article]

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