MOLECULAR MECHANISM OF PHOTOSIGNALING BY ARCHAEAL SENSORY RHODOPSINS Export

@article{citeulike:4636780, abstract = {▪ Abstract  Two sensory rhodopsins (SRI and SRII) mediate color-sensitive phototaxis responses in halobacteria. These seven-helix receptor proteins, structurally and functionally similar to animal visual pigments, couple retinal photoisomerization to receptor activation and are complexed with membrane-embedded transducer proteins (HtrI and HtrII) that modulate a cytoplasmic phosphorylation cascade controlling the flagellar motor. The Htr proteins resemble the chemotaxis transducers from Escherichia coli. The SR-Htr signaling complexes allow studies of the biophysical chemistry of signal generation and relay, from the photobiophysics of initial excitation of the receptors to the final output at the level of the flagellar motor switch, revealing fundamental principles of sensory transduction and more broadly the nature of dynamic interactions between membrane proteins. We review here recent advances that have led to new insights into the molecular mechanism of signaling by these membrane complexes.}, author = {Hoff, Wouter D. and Jung, Kwang H. and Spudich, John L.}, citeulike-article-id = {4636780}, citeulike-linkout-0 = {http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.biophys.26.1.223}, citeulike-linkout-1 = {http://dx.doi.org/10.1146/annurev.biophys.26.1.223}, doi = {10.1146/annurev.biophys.26.1.223}, journal = {Annual Review of Biophysics and Biomolecular Structure}, keywords = {background, function, mechanism, psrii, review, sri}, number = {1}, pages = {223--258}, posted-at = {2009-05-26 18:06:19}, priority = {0}, title = {MOLECULAR MECHANISM OF PHOTOSIGNALING BY ARCHAEAL SENSORY RHODOPSINS}, url = {http://dx.doi.org/10.1146/annurev.biophys.26.1.223}, volume = {26}, year = {1997} }

TY - JOUR ID - citeulike:4636780 L3 - citeulike-article-id:4636780 N2 - ▪ Abstract  Two sensory rhodopsins (SRI and SRII) mediate color-sensitive phototaxis responses in halobacteria. These seven-helix receptor proteins, structurally and functionally similar to animal visual pigments, couple retinal photoisomerization to receptor activation and are complexed with membrane-embedded transducer proteins (HtrI and HtrII) that modulate a cytoplasmic phosphorylation cascade controlling the flagellar motor. The Htr proteins resemble the chemotaxis transducers from Escherichia coli. The SR-Htr signaling complexes allow studies of the biophysical chemistry of signal generation and relay, from the photobiophysics of initial excitation of the receptors to the final output at the level of the flagellar motor switch, revealing fundamental principles of sensory transduction and more broadly the nature of dynamic interactions between membrane proteins. We review here recent advances that have led to new insights into the molecular mechanism of signaling by these membrane complexes. IS - 1 JF - Annual Review of Biophysics and Biomolecular Structure EP - 258 TI - MOLECULAR MECHANISM OF PHOTOSIGNALING BY ARCHAEAL SENSORY RHODOPSINS VL - 26 SP - 223 KW - background KW - function KW - mechanism KW - psrii KW - review KW - sri AU - Hoff, Wouter AU - Jung, Kwang AU - Spudich, John PY - 1997/// UR - http://dx.doi.org/10.1146/annurev.biophys.26.1.223 ER -