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The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review).

by: Jennifer Greaves, Gerald R. Prescott, Oforiwa A. Gorleku, Luke H. Chamberlain
Molecular membrane biology, Vol. 26, No. 1. (January 2009), pp. 67-79, doi:10.1080/09687680802620351  Key: citeulike:12011255

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Abstract

The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.


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