Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field Export

@article{citeulike:2616612, abstract = {At high and medium magnetic field, the transverse NMR relaxation rate (T2-1) of water protons in blood is determined predominantly by the oxygenation state of haemoglobin. T2-1 dependes quadratically on the field strength and on the proportion of haemoglobin that is deoxygenated. Deoxygenation increases the volume magnetic susceptibility within the erythrocytes and thus creates local field gradients around these cells. From volume susceptibility measurements and the dependence of T2-1 on the pulse rate in the Carr-Purcell-Meiboom-Gill experiment, we show that the increase in T2-1 with increasing blood deoxygenation arises from diffusion of water through these field gradients.}, author = {Thulborn, Keith R. and Waterton, John C. and Matthews, Paul M. and Radda, George K.}, citeulike-article-id = {2616612}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/0304-4165(82)90333-6}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6T1W-47MCP1S-12P/2/e0dec88b83f1af3512b9ed8648b0f4a9}, day = {2}, doi = {10.1016/0304-4165(82)90333-6}, journal = {Biochimica et Biophysica Acta (BBA) - General Subjects}, keywords = {blood-flow, bold, hemodynamic-response, relaxation-time}, month = {February}, number = {2}, pages = {265--270}, posted-at = {2008-03-31 16:32:33}, priority = {1}, title = {Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field}, url = {http://dx.doi.org/10.1016/0304-4165(82)90333-6}, volume = {714}, year = {1982} }

TY - JOUR ID - citeulike:2616612 L3 - citeulike-article-id:2616612 N2 - At high and medium magnetic field, the transverse NMR relaxation rate (T2-1) of water protons in blood is determined predominantly by the oxygenation state of haemoglobin. T2-1 dependes quadratically on the field strength and on the proportion of haemoglobin that is deoxygenated. Deoxygenation increases the volume magnetic susceptibility within the erythrocytes and thus creates local field gradients around these cells. From volume susceptibility measurements and the dependence of T2-1 on the pulse rate in the Carr-Purcell-Meiboom-Gill experiment, we show that the increase in T2-1 with increasing blood deoxygenation arises from diffusion of water through these field gradients. IS - 2 JF - Biochimica et Biophysica Acta (BBA) - General Subjects EP - 270 TI - Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field VL - 714 SP - 265 KW - blood-flow KW - bold KW - hemodynamic-response KW - relaxation-time AU - Thulborn, Keith AU - Waterton, John AU - Matthews, Paul AU - Radda, George PY - 1982/02/02/ UR - http://dx.doi.org/10.1016/0304-4165(82)90333-6 ER -