The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells. Export

@article{citeulike:489637, abstract = {Vertebrate limb outgrowth is driven by a positive feedback loop involving Sonic Hedgehog (Shh), Gremlin, and Fgf4. By overexpressing individual components of the loop at a time after these genes are normally down-regulated in chicken embryos, we found that Shh no longer maintains Gremlin in the posterior limb. Shh-expressing cells and their descendants cannot express Gremlin. The proliferation of these descendants forms a barrier separating the Shh signal from Gremlin-expressing cells, which breaks down the Shh-Fgf4 loop and thereby affects limb size and provides a mechanism explaining regulative properties of the limb bud.}, address = {Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.}, author = {Scherz, P. J. and Harfe, B. D. and McMahon, A. P. and Tabin, C. J.}, citeulike-article-id = {489637}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1096966}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/305/5682/396}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15256670}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15256670}, day = {16}, doi = {10.1126/science.1096966}, issn = {1095-9203}, journal = {Science}, keywords = {fgf4, h, hedgehog}, month = {July}, number = {5682}, pages = {396--399}, posted-at = {2008-10-08 20:36:10}, priority = {2}, title = {The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells.}, url = {http://dx.doi.org/10.1126/science.1096966}, volume = {305}, year = {2004} }

TY - JOUR ID - citeulike:489637 L3 - citeulike-article-id:489637 N2 - Vertebrate limb outgrowth is driven by a positive feedback loop involving Sonic Hedgehog (Shh), Gremlin, and Fgf4. By overexpressing individual components of the loop at a time after these genes are normally down-regulated in chicken embryos, we found that Shh no longer maintains Gremlin in the posterior limb. Shh-expressing cells and their descendants cannot express Gremlin. The proliferation of these descendants forms a barrier separating the Shh signal from Gremlin-expressing cells, which breaks down the Shh-Fgf4 loop and thereby affects limb size and provides a mechanism explaining regulative properties of the limb bud. IS - 5682 JF - Science SN - 1095-9203 AD - Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. EP - 399 TI - The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells. VL - 305 SP - 396 KW - fgf4 KW - h KW - hedgehog AU - Scherz, PJ AU - Harfe, BD AU - McMahon, AP AU - Tabin, CJ PY - 2004/07/16/ UR - http://dx.doi.org/10.1126/science.1096966 ER -