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Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING

by: Christian K. Holm, Soren B. Jensen, Martin R. Jakobsen, Natalia Cheshenko, Kristy A. Horan, Hanne B. Moeller, Regina Gonzalez-Dosal, Simon B. Rasmussen, Maria H. Christensen, Timur O. Yarovinsky, Frazer J. Rixon, Betsy C. Herold, Katherine A. Fitzgerald, Soren R. Paludan
Nat Immunol, Vol. 13, No. 8. (17 August 2012), pp. 737-743, doi:10.1038/ni.2350  Key: citeulike:10906307

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Abstract

Fusion with the cell membrane is the earliest event in viral infection. Paludan and colleagues show that 'unscheduled' membrane-fusion events elicit an innate immune response dependent on the adaptor STING.


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