An fMRI Study of the Role of the Medial Temporal Lobe in Implicit and Explicit Sequence Learning

by: Haline E Schendan, Meghan M Searl, Rebecca J Melrose, Chantal E Stern

Neuron, Vol. 37, No. 6. (27 March 2003), pp. 1013-1025.

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Abstract

fMRI was used to investigate the neural substrates supporting implicit and explicit sequence learning, focusing especially upon the role of the medial temporal lobe. Participants performed a serial reaction time task (SRTT). For implicit learning, they were naive about a repeating pattern, whereas for explicit learning, participants memorized another repeating sequence. fMRI analyses comparing repeating versus random sequence blocks demonstrated activation of frontal, parietal, cingulate, and striatal regions implicated in previous SRTT studies. Importantly, mediotemporal lobe regions were active in both explicit and implicit SRTT learning. Moreover, the results provide evidence of a role for the hippocampus and related cortices in the formation of higher order associations under both implicit and explicit learning conditions, regardless of conscious awareness of sequence knowledge.

@article{citeulike:2822448, abstract = {fMRI was used to investigate the neural substrates supporting implicit and explicit sequence learning, focusing especially upon the role of the medial temporal lobe. Participants performed a serial reaction time task (SRTT). For implicit learning, they were naive about a repeating pattern, whereas for explicit learning, participants memorized another repeating sequence. fMRI analyses comparing repeating versus random sequence blocks demonstrated activation of frontal, parietal, cingulate, and striatal regions implicated in previous SRTT studies. Importantly, mediotemporal lobe regions were active in both explicit and implicit SRTT learning. Moreover, the results provide evidence of a role for the hippocampus and related cortices in the formation of higher order associations under both implicit and explicit learning conditions, regardless of conscious awareness of sequence knowledge.}, author = {Schendan, Haline E. and Searl, Meghan M. and Melrose, Rebecca J. and Stern, Chantal E. }, citeulike-article-id = {2822448}, doi = {10.1016/S0896-6273(03)00123-5}, journal = {Neuron}, keywords = {explicit, implicit, learning, lobe, medial, temporal}, month = {March}, number = {6}, pages = {1013--1025}, posted-at = {2008-05-22 08:06:03}, priority = {2}, title = {An fMRI Study of the Role of the Medial Temporal Lobe in Implicit and Explicit Sequence Learning}, url = {http://dx.doi.org/10.1016/S0896-6273(03)00123-5}, volume = {37}, year = {2003} }

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TY - JOUR ID - citeulike:2822448 L3 - citeulike-article-id:2822448 TI - An fMRI Study of the Role of the Medial Temporal Lobe in Implicit and Explicit Sequence Learning JF - Neuron VL - 37 IS - 6 SP - 1013 EP - 1025 N2 - fMRI was used to investigate the neural substrates supporting implicit and explicit sequence learning, focusing especially upon the role of the medial temporal lobe. Participants performed a serial reaction time task (SRTT). For implicit learning, they were naive about a repeating pattern, whereas for explicit learning, participants memorized another repeating sequence. fMRI analyses comparing repeating versus random sequence blocks demonstrated activation of frontal, parietal, cingulate, and striatal regions implicated in previous SRTT studies. Importantly, mediotemporal lobe regions were active in both explicit and implicit SRTT learning. Moreover, the results provide evidence of a role for the hippocampus and related cortices in the formation of higher order associations under both implicit and explicit learning conditions, regardless of conscious awareness of sequence knowledge. KW - explicit KW - implicit KW - learning KW - lobe KW - medial KW - temporal AU - Schendan, Haline AU - Searl, Meghan AU - Melrose, Rebecca AU - Stern, Chantal PY - 2003/03/27/ UR - http://dx.doi.org/10.1016/S0896-6273(03)00123-5 ER -

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