Risk of breast, ovary, and uterine corpus cancers among 85,268 women with AIDS. Export

@article{citeulike:775706, abstract = {By linking HIV/AIDS and cancer surveillance data in 12 US regions, breast and reproductive cancer risks with AIDS were compared to those in the general population. Trends in standardized incidence ratios (SIRs) were assessed by CD4 count, AIDS-relative time, and calendar time. Standardized incidence ratios were indirectly adjusted for cancer risk factors using data from AIDS cohort participants and the general population. With AIDS, 313 women developed breast cancer (SIR 0.69, 95\% confidence interval (CI) 0.62-0.77), 42 developed ovary cancer (SIR 1.05, 95\% CI, 0.75-1.42), and 31 developed uterine corpus cancer (SIR 0.57, 95\% CI, 0.39-0.81). Uterine cancer risk was reduced significantly after age 50 (SIR 0.33). Breast cancer risk was reduced significantly both before (SIR 0.71) and after (SIR 0.66) age 50, and was lower for local or regional (SIR 0.54) than distant (SIR 0.89) disease. Breast cancer risk varied little by CD4 count (Ptrend=0.47) or AIDS-relative time (Ptrend=0.14) or after adjustment for established cancer risk factors. However, it increased significantly between 1980 and 2002 (Ptrend=0.003), approaching the risk of the general population. We conclude that the cancer deficit reflected direct or indirect effects of HIV/AIDS and that anti-HIV therapy reduced these effects.}, author = {Goedert, J. J. and Schairer, C. and McNeel, T. S. and Hessol, N. A. and Rabkin, C. S. and Engels, E. A. and {HIV/AIDS Cancer Match Study}}, citeulike-article-id = {775706}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/sj.bjc.6603282}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16868538}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16868538}, day = {4}, doi = {10.1038/sj.bjc.6603282}, issn = {0007-0920}, journal = {British journal of cancer}, keywords = {breast-cancer, hiv, ovarian-cancer, uterine-cancer, women}, month = {September}, number = {5}, pages = {642--648}, posted-at = {2009-10-23 05:46:46}, priority = {2}, publisher = {Nature Publishing Group}, title = {Risk of breast, ovary, and uterine corpus cancers among 85,268 women with AIDS.}, url = {http://dx.doi.org/10.1038/sj.bjc.6603282}, volume = {95}, year = {2006} }

TY - JOUR ID - citeulike:775706 L3 - citeulike-article-id:775706 N2 - By linking HIV/AIDS and cancer surveillance data in 12 US regions, breast and reproductive cancer risks with AIDS were compared to those in the general population. Trends in standardized incidence ratios (SIRs) were assessed by CD4 count, AIDS-relative time, and calendar time. Standardized incidence ratios were indirectly adjusted for cancer risk factors using data from AIDS cohort participants and the general population. With AIDS, 313 women developed breast cancer (SIR 0.69, 95% confidence interval (CI) 0.62-0.77), 42 developed ovary cancer (SIR 1.05, 95% CI, 0.75-1.42), and 31 developed uterine corpus cancer (SIR 0.57, 95% CI, 0.39-0.81). Uterine cancer risk was reduced significantly after age 50 (SIR 0.33). Breast cancer risk was reduced significantly both before (SIR 0.71) and after (SIR 0.66) age 50, and was lower for local or regional (SIR 0.54) than distant (SIR 0.89) disease. Breast cancer risk varied little by CD4 count (Ptrend=0.47) or AIDS-relative time (Ptrend=0.14) or after adjustment for established cancer risk factors. However, it increased significantly between 1980 and 2002 (Ptrend=0.003), approaching the risk of the general population. We conclude that the cancer deficit reflected direct or indirect effects of HIV/AIDS and that anti-HIV therapy reduced these effects. IS - 5 JF - British journal of cancer SN - 0007-0920 EP - 648 TI - Risk of breast, ovary, and uterine corpus cancers among 85,268 women with AIDS. PB - Nature Publishing Group VL - 95 SP - 642 KW - breast-cancer KW - hiv KW - ovarian-cancer KW - uterine-cancer KW - women AU - Goedert, JJ AU - Schairer, C AU - McNeel, TS AU - Hessol, NA AU - Rabkin, CS AU - Engels, EA PY - 2006/09/04/ UR - http://dx.doi.org/10.1038/sj.bjc.6603282 ER -