Genetic basis of systemic lupus erythematosus: a review of the unique genetic contributions in African Americans. Export

@article{citeulike:3347874, abstract = {Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving critical genetic and environmental risk factors. SLE is a relatively common disease among African American women, affecting as many as one in 250. A collection of more than 250 African American and European American pedigrees multiplex for SLE have been collected in Oklahoma over the past decade for the purpose of identifying the genetic risk factors involved in the pathogenesis of SLE. A genome scan has been performed, and interestingly, the linkage results usually dominate in families from one or the other of these ethnicities. For example, the linkage effect at 1q21-22 near FcgammaRIIA is much stronger in the African American pedigrees than in the European American pedigrees. On the other hand, a gene near the top of chromosome4 (at 4p l6-15) contributes to SLE in the European American pedigrees, but not in the African American pedigrees. The racially-specific results lead to the tentative conclusion of genetic differences associated with SLE in African Americans and European Americans. The identification of the genes responsible for the observed linkage effects will provide fundamental knowledge concerning SLE and may even provide new targets for therapy and strategies to defeat this enigmatic and difficult disease.}, address = {University of Oklahoma Health Sciences Center, Oklahoma City, USA. john-harley@mail.omrf.ouhsc.edu}, author = {Harley, J. B. and Kelly, J. A.}, citeulike-article-id = {3347874}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12152922}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12152922}, issn = {0027-9684}, journal = {Journal of the National Medical Association}, keywords = {aa, genetic, sle}, month = {August}, number = {8}, pages = {670--677}, posted-at = {2008-09-28 21:55:58}, priority = {2}, title = {Genetic basis of systemic lupus erythematosus: a review of the unique genetic contributions in African Americans.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12152922}, volume = {94}, year = {2002} }

TY - JOUR ID - citeulike:3347874 L3 - citeulike-article-id:3347874 N2 - Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving critical genetic and environmental risk factors. SLE is a relatively common disease among African American women, affecting as many as one in 250. A collection of more than 250 African American and European American pedigrees multiplex for SLE have been collected in Oklahoma over the past decade for the purpose of identifying the genetic risk factors involved in the pathogenesis of SLE. A genome scan has been performed, and interestingly, the linkage results usually dominate in families from one or the other of these ethnicities. For example, the linkage effect at 1q21-22 near FcgammaRIIA is much stronger in the African American pedigrees than in the European American pedigrees. On the other hand, a gene near the top of chromosome4 (at 4p l6-15) contributes to SLE in the European American pedigrees, but not in the African American pedigrees. The racially-specific results lead to the tentative conclusion of genetic differences associated with SLE in African Americans and European Americans. The identification of the genes responsible for the observed linkage effects will provide fundamental knowledge concerning SLE and may even provide new targets for therapy and strategies to defeat this enigmatic and difficult disease. IS - 8 JF - Journal of the National Medical Association SN - 0027-9684 AD - University of Oklahoma Health Sciences Center, Oklahoma City, USA. john-harley@mail.omrf.ouhsc.edu EP - 677 TI - Genetic basis of systemic lupus erythematosus: a review of the unique genetic contributions in African Americans. VL - 94 SP - 670 KW - aa KW - genetic KW - sle AU - Harley, JB AU - Kelly, JA PY - 2002/08// UR - http://view.ncbi.nlm.nih.gov/pubmed/12152922 ER -