Regulation of autoimmune inflammation by pro-inflammatory cytokines. Export

@article{citeulike:3349418, abstract = {The pro-inflammatory cytokines play a critical role in the initiation and propagation of autoimmune arthritis and many other disorders resulting from a dysregulated self-directed immune response. These cytokines influence the interplay among the cellular, immunological and biochemical mediators of inflammation at multiple levels. Regulation of the pro-inflammatory activity of these cytokines is generally perceived to be mediated by the anti-inflammatory and immunosuppressive cytokines such as IL-4, IL-10, or TGF-beta. However, increasing evidence is accumulating in support of the regulatory attributes of the pro-inflammatory cytokines themselves, in studies conducted in animal models of diabetes, multiple sclerosis, uveitis, and lupus. The results of our recent studies have shown that the pro-inflammatory cytokines, TNF-alpha and IFN-gamma, can suppress arthritic inflammation in rats, and also contribute to resistance against arthritis. These results are of paramount significance not only in fully understanding the pathogenesis of autoimmune arthritis, but also in anticipating the full ramifications of the in vivo neutralization of the pro-inflammatory cytokines, including that for therapeutic purposes.}, address = {Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.}, author = {Kim, Eugene Y. and Moudgil, Kamal D.}, citeulike-article-id = {3349418}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.imlet.2008.07.008}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18694783}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18694783}, day = {30}, doi = {10.1016/j.imlet.2008.07.008}, issn = {0165-2478}, journal = {Immunology letters}, keywords = {autoimmunity, cytokines, inflammatory}, month = {October}, number = {1-2}, pages = {1--5}, posted-at = {2008-09-29 01:43:34}, priority = {2}, title = {Regulation of autoimmune inflammation by pro-inflammatory cytokines.}, url = {http://dx.doi.org/10.1016/j.imlet.2008.07.008}, volume = {120}, year = {2008} }

TY - JOUR ID - citeulike:3349418 L3 - citeulike-article-id:3349418 N2 - The pro-inflammatory cytokines play a critical role in the initiation and propagation of autoimmune arthritis and many other disorders resulting from a dysregulated self-directed immune response. These cytokines influence the interplay among the cellular, immunological and biochemical mediators of inflammation at multiple levels. Regulation of the pro-inflammatory activity of these cytokines is generally perceived to be mediated by the anti-inflammatory and immunosuppressive cytokines such as IL-4, IL-10, or TGF-beta. However, increasing evidence is accumulating in support of the regulatory attributes of the pro-inflammatory cytokines themselves, in studies conducted in animal models of diabetes, multiple sclerosis, uveitis, and lupus. The results of our recent studies have shown that the pro-inflammatory cytokines, TNF-alpha and IFN-gamma, can suppress arthritic inflammation in rats, and also contribute to resistance against arthritis. These results are of paramount significance not only in fully understanding the pathogenesis of autoimmune arthritis, but also in anticipating the full ramifications of the in vivo neutralization of the pro-inflammatory cytokines, including that for therapeutic purposes. IS - 1-2 JF - Immunology letters SN - 0165-2478 AD - Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA. EP - 5 TI - Regulation of autoimmune inflammation by pro-inflammatory cytokines. VL - 120 SP - 1 KW - autoimmunity KW - cytokines KW - inflammatory AU - Kim, Eugene AU - Moudgil, Kamal PY - 2008/10/30/ UR - http://dx.doi.org/10.1016/j.imlet.2008.07.008 ER -