Vasoactive Intestinal Peptide Is Critical for Circadian Regulation of Glucocorticoids. Export

@article{citeulike:3170998, abstract = {Background/Aims: Circadian control of behavior and physiology is a central characteristic of all living organisms. The master clock in mammals resides in the hypothalamus, where the suprachiasmatic nucleus (SCN) synchronizes daily rhythms. A variety of recent evidence indicates that the neuropeptide vasoactive intestinal peptide (VIP) is critical for normal functioning of the SCN. The aim of our study was to examine the possible role of VIP in driving circadian rhythms in the hypothalamic-pituitary-adrenal axis. Methods: Circulating ACTH and corticosterone concentrations were determined by round-the-clock sampling under diurnal and circadian conditions. The responsive aspects of the hypothalamic-pituitary-adrenal axis were tested by application of acute stress by footshock and light. Results: We demonstrate that the circadian rhythms in ACTH and corticosterone are lost in VIP-deficient mice. The ability of light to induce a corticosterone response was also compromised in the mutant mice, as was photic induction of Per1 in the adrenal glands. In contrast, the acute stress response was apparently unaltered by the loss of VIP. Conclusion: Thus, our data demonstrate that VIP is essential for the circadian regulation of an otherwise intact hypothalamic-pituitary-adrenal axis.}, address = {Semel Institute for Neuroscience, Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Calif., USA.}, author = {Loh, Dawn H. and Abad, Catalina and Colwell, Christopher S. and Waschek, James A.}, citeulike-article-id = {3170998}, citeulike-linkout-0 = {http://dx.doi.org/10.1159/000140676}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18562786}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18562786}, comment = {VIP KO mice lack diurnal and circadian rhythms in serum corticosterone and ACTH. Light fails to causes an increase in circulating [corticosterone] in VIP KO mice, although stress-induced increase remains intact. Suggests some HPA axis function remains (possibly due to redundancy), but that VIP is critical for response of periphery to light.}, day = {19}, doi = {10.1159/000140676}, issn = {1423-0194}, journal = {Neuroendocrinology}, keywords = {adrenals, circadian, corticosterone, glucocorticoids, hpa\_axis, own, vip}, month = {June}, posted-at = {2008-08-29 03:33:14}, priority = {0}, title = {Vasoactive Intestinal Peptide Is Critical for Circadian Regulation of Glucocorticoids.}, url = {http://dx.doi.org/10.1159/000140676}, year = {2008} }

TY - JOUR ID - citeulike:3170998 L3 - citeulike-article-id:3170998 N2 - Background/Aims: Circadian control of behavior and physiology is a central characteristic of all living organisms. The master clock in mammals resides in the hypothalamus, where the suprachiasmatic nucleus (SCN) synchronizes daily rhythms. A variety of recent evidence indicates that the neuropeptide vasoactive intestinal peptide (VIP) is critical for normal functioning of the SCN. The aim of our study was to examine the possible role of VIP in driving circadian rhythms in the hypothalamic-pituitary-adrenal axis. Methods: Circulating ACTH and corticosterone concentrations were determined by round-the-clock sampling under diurnal and circadian conditions. The responsive aspects of the hypothalamic-pituitary-adrenal axis were tested by application of acute stress by footshock and light. Results: We demonstrate that the circadian rhythms in ACTH and corticosterone are lost in VIP-deficient mice. The ability of light to induce a corticosterone response was also compromised in the mutant mice, as was photic induction of Per1 in the adrenal glands. In contrast, the acute stress response was apparently unaltered by the loss of VIP. Conclusion: Thus, our data demonstrate that VIP is essential for the circadian regulation of an otherwise intact hypothalamic-pituitary-adrenal axis. JF - Neuroendocrinology SN - 1423-0194 AD - Semel Institute for Neuroscience, Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Calif., USA. TI - Vasoactive Intestinal Peptide Is Critical for Circadian Regulation of Glucocorticoids. KW - adrenals KW - circadian KW - corticosterone KW - glucocorticoids KW - hpa_axis KW - own KW - vip N1 - VIP KO mice lack diurnal and circadian rhythms in serum corticosterone and ACTH. Light fails to causes an increase in circulating [corticosterone] in VIP KO mice, although stress-induced increase remains intact. Suggests some HPA axis function remains (possibly due to redundancy), but that VIP is critical for response of periphery to light. AU - Loh, Dawn AU - Abad, Catalina AU - Colwell, Christopher AU - Waschek, James PY - 2008/06/19/ UR - http://dx.doi.org/10.1159/000140676 ER -