Lack of light-induced elevation of renal sympathetic nerve activity and plasma corticosterone levels in PACAP-deficient mice. Export

@article{citeulike:3179770, abstract = {PACAP is a neurotransmitter involved in the signal transduction of light stimulation in the suprachiasmatic nucleus (SCN). Light stimulation affects autonomic nerve activity via the SCN, and here we tested whether PACAP participates in light-induced regulation of sympatho-adrenal activity by using PACAP-deficient (Adcyap1(-/-)) mice. Light stimulation (100 lux, 30min) significantly elevated both renal sympathetic nerve activity (RSNA), which was monitored on a digital oscilloscope, and plasma corticosterone levels in wild-type mice, but both responses were almost abolished in Adcyap1(-/-) mice. Although light-induced c-Fos expression in the SCN was observed in both genotypes, the numbers of c-Fos positive cells were significantly decreased in Adcyap1(-/-) mice. These data suggest that PACAP signaling pathway is involved in light-induced stimulation of RSNA and plasma corticosterone release through SCN of brain.}, address = {Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.}, author = {Hatanaka, Michiyoshi and Tanida, Mamoru and Shintani, Norihito and Isojima, Yasushi and Kawaguchi, Chihiro and Hashimoto, Hitoshi and Kakuda, Michiya and Haba, Ryota and Nagai, Katsuya and Baba, Akemichi}, citeulike-article-id = {3179770}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neulet.2008.08.030}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18722505}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18722505}, comment = {Authors report that PACAP KO mice fail to show the expected increase in renal sympathetic nerve activity, circulating corticosterone (plasma), and cFOS expression in SCN. This finding is similar to the VIP KO model, which also shows deficits in the light-responsive pathways. Unfortunately, it does not bring us any closer to determining whether the presence of these neuropeptides is crucial in the brain or in the peripheral nervous system.}, day = {15}, doi = {10.1016/j.neulet.2008.08.030}, issn = {0304-3940}, journal = {Neuroscience letters}, keywords = {adrenals, corticosterone, pacap}, month = {August}, posted-at = {2008-09-01 19:58:12}, priority = {0}, title = {Lack of light-induced elevation of renal sympathetic nerve activity and plasma corticosterone levels in PACAP-deficient mice.}, url = {http://dx.doi.org/10.1016/j.neulet.2008.08.030}, year = {2008} }

TY - JOUR ID - citeulike:3179770 L3 - citeulike-article-id:3179770 N2 - PACAP is a neurotransmitter involved in the signal transduction of light stimulation in the suprachiasmatic nucleus (SCN). Light stimulation affects autonomic nerve activity via the SCN, and here we tested whether PACAP participates in light-induced regulation of sympatho-adrenal activity by using PACAP-deficient (Adcyap1(-/-)) mice. Light stimulation (100 lux, 30min) significantly elevated both renal sympathetic nerve activity (RSNA), which was monitored on a digital oscilloscope, and plasma corticosterone levels in wild-type mice, but both responses were almost abolished in Adcyap1(-/-) mice. Although light-induced c-Fos expression in the SCN was observed in both genotypes, the numbers of c-Fos positive cells were significantly decreased in Adcyap1(-/-) mice. These data suggest that PACAP signaling pathway is involved in light-induced stimulation of RSNA and plasma corticosterone release through SCN of brain. JF - Neuroscience letters SN - 0304-3940 AD - Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. TI - Lack of light-induced elevation of renal sympathetic nerve activity and plasma corticosterone levels in PACAP-deficient mice. KW - adrenals KW - corticosterone KW - pacap N1 - Authors report that PACAP KO mice fail to show the expected increase in renal sympathetic nerve activity, circulating corticosterone (plasma), and cFOS expression in SCN. This finding is similar to the VIP KO model, which also shows deficits in the light-responsive pathways. Unfortunately, it does not bring us any closer to determining whether the presence of these neuropeptides is crucial in the brain or in the peripheral nervous system. AU - Hatanaka, Michiyoshi AU - Tanida, Mamoru AU - Shintani, Norihito AU - Isojima, Yasushi AU - Kawaguchi, Chihiro AU - Hashimoto, Hitoshi AU - Kakuda, Michiya AU - Haba, Ryota AU - Nagai, Katsuya AU - Baba, Akemichi PY - 2008/08/15/ UR - http://dx.doi.org/10.1016/j.neulet.2008.08.030 ER -