Multidrug-resistance efflux pumps - not just for resistance. Export

@article{Piddock2006, abstract = {It is well established that multidrug-resistance efflux pumps encoded by bacteria can confer clinically relevant resistance to antibiotics. It is now understood that these efflux pumps also have a physiological role(s). They can confer resistance to natural substances produced by the host, including bile, hormones and host-defence molecules. In addition, some efflux pumps of the resistance nodulation division (RND) family have been shown to have a role in the colonization and the persistence of bacteria in the host. Here, I present the accumulating evidence that multidrug-resistance efflux pumps have roles in bacterial pathogenicity and propose that these pumps therefore have greater clinical relevance than is usually attributed to them.}, author = {Piddock, Laura J. V.}, citeulike-article-id = {2318689}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrmicro1464}, doi = {10.1038/nrmicro1464}, journal = {Nat Rev Microbiol}, keywords = {atp-binding, bac, bacteria, bacterial, carrier, cassette, coli, drug, escherichia, from\_jabref, membrane, microbial, multidrug, multiple, outer, physiology, proteins, resistance, resistance-associated, sensitivity, terial, tests, transport, transporters, virulence}, month = {Aug}, number = {8}, pages = {629--636}, pdf = {Efflux review.pdf}, posted-at = {2008-02-01 09:55:10}, priority = {2}, title = {Multidrug-resistance efflux pumps - not just for resistance.}, url = {10.1038/nrmicro1464}, volume = {4}, year = {2006} }

TY - JOUR ID - Piddock2006 L3 - citeulike-article-id:2318689 N2 - It is well established that multidrug-resistance efflux pumps encoded by bacteria can confer clinically relevant resistance to antibiotics. It is now understood that these efflux pumps also have a physiological role(s). They can confer resistance to natural substances produced by the host, including bile, hormones and host-defence molecules. In addition, some efflux pumps of the resistance nodulation division (RND) family have been shown to have a role in the colonization and the persistence of bacteria in the host. Here, I present the accumulating evidence that multidrug-resistance efflux pumps have roles in bacterial pathogenicity and propose that these pumps therefore have greater clinical relevance than is usually attributed to them. IS - 8 JF - Nat Rev Microbiol EP - 636 TI - Multidrug-resistance efflux pumps - not just for resistance. VL - 4 SP - 629 KW - atp-binding KW - bac KW - bacteria KW - bacterial KW - carrier KW - cassette KW - coli KW - drug KW - escherichia KW - from_jabref KW - membrane KW - microbial KW - multidrug KW - multiple KW - outer KW - physiology KW - proteins KW - resistance KW - resistance-associated KW - sensitivity KW - terial KW - tests KW - transport KW - transporters KW - virulence AU - Piddock, Laura PY - 2006/Aug// UR - http://dx.doi.org/10.1038/nrmicro1464 ER -