Genetic structure of human populations. Export

@article{Rosenberg2002, abstract = {We studied human population structure using genotypes at 377 autosomal microsatellite loci in 1056 individuals from 52 populations. Within-population differences among individuals account for 93 to 95\\% of genetic variation; differences among major groups constitute only 3 to 5\\%. Nevertheless, without using prior information about the origins of individuals, we identified six main genetic clusters, five of which correspond to major geographic regions, and subclusters that often correspond to individual populations. General agreement of genetic and predefined populations suggests that self-reported ancestry can facilitate assessments of epidemiological risks but does not obviate the need to use genetic information in genetic association studies.}, author = {Rosenberg, Noah A. and Pritchard, Jonathan K. and Weber, James L. and Cann, Howard M. and Kidd, Kenneth K. and Zhivotovsky, Lev A. and Feldman, Marcus W.}, citeulike-article-id = {2318697}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1078311}, doi = {10.1126/science.1078311}, journal = {Science}, keywords = {africa, algorithms, alleles, americas, analysis, asia, cluster, disease, drift, east, europe, factors, frequency, from\_jabref, gene, genetic, genetics, genotype, geography, heterozygote, humans, islands, language, medical, microsatellite, middle, of, pacific, population, predisposition, probability, repeats, risk, sahara, south, the, to, variance, variation}, month = {Dec}, number = {5602}, pages = {2381--2385}, pdf = {human\_pop\_gen\_str.pdf}, posted-at = {2008-02-01 09:55:12}, priority = {2}, title = {Genetic structure of human populations.}, url = {10.1126/science.1078311}, volume = {298}, year = {2002} }

TY - JOUR ID - Rosenberg2002 L3 - citeulike-article-id:2318697 N2 - We studied human population structure using genotypes at 377 autosomal microsatellite loci in 1056 individuals from 52 populations. Within-population differences among individuals account for 93 to 95\\% of genetic variation; differences among major groups constitute only 3 to 5\\%. Nevertheless, without using prior information about the origins of individuals, we identified six main genetic clusters, five of which correspond to major geographic regions, and subclusters that often correspond to individual populations. General agreement of genetic and predefined populations suggests that self-reported ancestry can facilitate assessments of epidemiological risks but does not obviate the need to use genetic information in genetic association studies. IS - 5602 JF - Science EP - 2385 TI - Genetic structure of human populations. VL - 298 SP - 2381 KW - africa KW - algorithms KW - alleles KW - americas KW - analysis KW - asia KW - cluster KW - disease KW - drift KW - east KW - europe KW - factors KW - frequency KW - from_jabref KW - gene KW - genetic KW - genetics KW - genotype KW - geography KW - heterozygote KW - humans KW - islands KW - language KW - medical KW - microsatellite KW - middle KW - of KW - pacific KW - population KW - predisposition KW - probability KW - repeats KW - risk KW - sahara KW - south KW - the KW - to KW - variance KW - variation AU - Rosenberg, Noah AU - Pritchard, Jonathan AU - Weber, James AU - Cann, Howard AU - Kidd, Kenneth AU - Zhivotovsky, Lev AU - Feldman, Marcus PY - 2002/Dec// UR - http://dx.doi.org/10.1126/science.1078311 ER -