MicroRNA enrichment among short 'ultraconserved' sequences in insects. Export

@article{Tran2006, abstract = {MicroRNAs are short (approximately 22 nt) regulatory RNA molecules that play key roles in metazoan development and have been implicated in human disease. First discovered in Caenorhabditis elegans, over 2500 microRNAs have been isolated in metazoans and plants; it has been estimated that there may be more than a thousand microRNA genes in the human genome alone. Motivated by the experimental observation of strong conservation of the microRNA let-7 among nearly all metazoans, we developed a novel methodology to characterize the class of such strongly conserved sequences: we identified a non-redundant set of all sequences 20 to 29 bases in length that are shared among three insects: fly, bee and mosquito. Among the few hundred sequences greater than 20 bases in length are close to 40\\ of the 78 confirmed fly microRNAs, along with other non-coding RNAs and coding sequence.}, author = {Tran, T. and Havlak, P. and Miller, J.}, citeulike-article-id = {2318708}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/nar/gkl173}, doi = {10.1093/nar/gkl173}, journal = {Nucleic Acids Res}, keywords = {animals, anopheles, base, bees, conserved, drosophila, extramural, from\_jabref, gambiae, genome, genomics, govt, insect, melanogaster, micrornas, nih, non-us, research, sequence, support}, number = {9}, posted-at = {2008-02-01 09:55:14}, priority = {2}, title = {MicroRNA enrichment among short 'ultraconserved' sequences in insects.}, url = {10.1093/nar/gkl173}, volume = {34}, year = {2006} }

TY - JOUR ID - Tran2006 L3 - citeulike-article-id:2318708 N2 - MicroRNAs are short (approximately 22 nt) regulatory RNA molecules that play key roles in metazoan development and have been implicated in human disease. First discovered in Caenorhabditis elegans, over 2500 microRNAs have been isolated in metazoans and plants; it has been estimated that there may be more than a thousand microRNA genes in the human genome alone. Motivated by the experimental observation of strong conservation of the microRNA let-7 among nearly all metazoans, we developed a novel methodology to characterize the class of such strongly conserved sequences: we identified a non-redundant set of all sequences 20 to 29 bases in length that are shared among three insects: fly, bee and mosquito. Among the few hundred sequences greater than 20 bases in length are close to 40\\ of the 78 confirmed fly microRNAs, along with other non-coding RNAs and coding sequence. IS - 9 JF - Nucleic Acids Res TI - MicroRNA enrichment among short 'ultraconserved' sequences in insects. VL - 34 KW - animals KW - anopheles KW - base KW - bees KW - conserved KW - drosophila KW - extramural KW - from_jabref KW - gambiae KW - genome KW - genomics KW - govt KW - insect KW - melanogaster KW - micrornas KW - nih KW - non-us KW - research KW - sequence KW - support AU - Tran, T AU - Havlak, P AU - Miller, J PY - 2006/// UR - http://dx.doi.org/10.1093/nar/gkl173 ER -