Kinomer v. 1.0: a database of systematically classified eukaryotic protein kinases Export

@article{citeulike:3477272, abstract = {The regulation of protein function through reversible phosphorylation by protein kinases and phosphatases is a general mechanism controlling virtually every cellular activity. Eukaryotic protein kinases can be classified into distinct, well-characterized groups based on amino acid sequence similarity and function. We recently reported a highly sensitive and accurate hidden Markov model-based method for the automatic detection and classification of protein kinases into these specific groups. The Kinomer v. 1.0 database presented here contains annotated classifications for the protein kinase complements of 43 eukaryotic genomes. These span the taxonomic range and include fungi (16 species), plants (6), diatoms (1), amoebas (2), protists (1) and animals (17). The kinomes are stored in a relational database and are accessible through a web interface on the basis of species, kinase group or a combination of both. In addition, the Kinomer v. 1.0 HMM library is made available for users to perform classification on arbitrary sequences. The Kinomer v. 1.0 database is a continually updated resource where direct comparison of kinase sequences across kinase groups and across species can give insights into kinase function and evolution. Kinomer v. 1.0 is available at http://www.compbio.dundee.ac.uk/kinomer/. 10.1093/nar/gkn834}, author = {Martin, David M. A. and Miranda-Saavedra, Diego and Barton, Geoffrey J.}, citeulike-article-id = {3477272}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/nar/gkn834}, citeulike-linkout-1 = {http://nar.oxfordjournals.org/cgi/content/abstract/37/suppl_1/D244?etoc}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18974176}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18974176}, day = {1}, doi = {10.1093/nar/gkn834}, journal = {Nucl. Acids Res.}, keywords = {arabidopsis, biocad, database, phosphoproteomic}, month = {January}, number = {suppl\_1}, pages = {D244--250}, posted-at = {2009-02-18 13:45:47}, priority = {2}, title = {Kinomer v. 1.0: a database of systematically classified eukaryotic protein kinases}, url = {http://dx.doi.org/10.1093/nar/gkn834}, volume = {37}, year = {2009} }

TY - JOUR ID - citeulike:3477272 L3 - citeulike-article-id:3477272 N2 - The regulation of protein function through reversible phosphorylation by protein kinases and phosphatases is a general mechanism controlling virtually every cellular activity. Eukaryotic protein kinases can be classified into distinct, well-characterized groups based on amino acid sequence similarity and function. We recently reported a highly sensitive and accurate hidden Markov model-based method for the automatic detection and classification of protein kinases into these specific groups. The Kinomer v. 1.0 database presented here contains annotated classifications for the protein kinase complements of 43 eukaryotic genomes. These span the taxonomic range and include fungi (16 species), plants (6), diatoms (1), amoebas (2), protists (1) and animals (17). The kinomes are stored in a relational database and are accessible through a web interface on the basis of species, kinase group or a combination of both. In addition, the Kinomer v. 1.0 HMM library is made available for users to perform classification on arbitrary sequences. The Kinomer v. 1.0 database is a continually updated resource where direct comparison of kinase sequences across kinase groups and across species can give insights into kinase function and evolution. Kinomer v. 1.0 is available at http://www.compbio.dundee.ac.uk/kinomer/. 10.1093/nar/gkn834 IS - suppl_1 JF - Nucl. Acids Res. EP - 250 TI - Kinomer v. 1.0: a database of systematically classified eukaryotic protein kinases VL - 37 SP - D244 KW - arabidopsis KW - biocad KW - database KW - phosphoproteomic AU - Martin, David AU - Miranda-Saavedra, Diego AU - Barton, Geoffrey PY - 2009/01/01/ UR - http://dx.doi.org/10.1093/nar/gkn834 ER -