One Hundred Years After "Carcinoid": Epidemiology of and Prognostic Factors for Neuroendocrine Tumors in 35,825 Cases in the United States Export

@article{citeulike:3667112, abstract = {PurposeNeuroendocrine tumors (NETs) are considered rare tumors and can produce a variety of hormones. In this study, we examined the epidemiology of and prognostic factors for NETs, because a thorough examination of neither had previously been performed. MethodsThe Surveillance, Epidemiology, and End Results (SEER) Program registries were searched to identify NET cases from 1973 to 2004. Associated population data were used for incidence and prevalence analyses. ResultsWe identified 35,618 patients with NETs. We observed a significant increase in the reported annual age-adjusted incidence of NETs from 1973 (1.09/100,000) to 2004 (5.25/100,000). Using the SEER 9 registry data, we estimated the 29-year limited-duration prevalence of NETs on January 1, 2004, to be 9,263. Also, the estimated 29-year limited-duration prevalence in the United States on that date was 103,312 cases (35/100,000). The most common primary tumor site varied by race, with the lung being the most common in white patients, and the rectum being the most common in Asian/Pacific Islander, American Indian/Alaskan Native, and African American patients. Additionally, survival duration varied by histologic grade. In multivariate analysis of patients with well-differentiated to moderately differentiated NETs, disease stage, primary tumor site, histologic grade, sex, race, age, and year of diagnosis were predictors of outcome (P < .001). ConclusionWe observed increased reported incidence of NETs and increased survival durations over time, suggesting that NETs are more prevalent than previously reported. Clinicians need to be become familiar with the natural history and patterns of disease progression, which are characteristic of these tumors. 10.1200/JCO.2007.15.4377}, author = {Yao, James C. and Hassan, Manal and Phan, Alexandria and Dagohoy, Cecile and Leary, Colleen and Mares, Jeannette E. and Abdalla, Eddie K. and Fleming, Jason B. and Vauthey, Jean-Nicolas and Rashid, Asif and Evans, Douglas B.}, citeulike-article-id = {3667112}, citeulike-linkout-0 = {http://dx.doi.org/10.1200/JCO.2007.15.4377}, citeulike-linkout-1 = {http://jco.ascopubs.org/content/26/18/3063.abstract}, citeulike-linkout-2 = {http://jco.ascopubs.org/content/26/18/3063.full.pdf}, citeulike-linkout-3 = {http://jco.ascopubs.org/cgi/content/abstract/26/18/3063}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/18565894}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=18565894}, day = {20}, doi = {10.1200/JCO.2007.15.4377}, journal = {J Clin Oncol}, keywords = {carcinoid}, month = {June}, number = {18}, pages = {3063--3072}, posted-at = {2008-11-23 20:15:31}, priority = {2}, title = {One Hundred Years After "Carcinoid": Epidemiology of and Prognostic Factors for Neuroendocrine Tumors in 35,825 Cases in the United States}, url = {http://dx.doi.org/10.1200/JCO.2007.15.4377}, volume = {26}, year = {2008} }

TY - JOUR ID - citeulike:3667112 L3 - citeulike-article-id:3667112 N2 - PurposeNeuroendocrine tumors (NETs) are considered rare tumors and can produce a variety of hormones. In this study, we examined the epidemiology of and prognostic factors for NETs, because a thorough examination of neither had previously been performed. MethodsThe Surveillance, Epidemiology, and End Results (SEER) Program registries were searched to identify NET cases from 1973 to 2004. Associated population data were used for incidence and prevalence analyses. ResultsWe identified 35,618 patients with NETs. We observed a significant increase in the reported annual age-adjusted incidence of NETs from 1973 (1.09/100,000) to 2004 (5.25/100,000). Using the SEER 9 registry data, we estimated the 29-year limited-duration prevalence of NETs on January 1, 2004, to be 9,263. Also, the estimated 29-year limited-duration prevalence in the United States on that date was 103,312 cases (35/100,000). The most common primary tumor site varied by race, with the lung being the most common in white patients, and the rectum being the most common in Asian/Pacific Islander, American Indian/Alaskan Native, and African American patients. Additionally, survival duration varied by histologic grade. In multivariate analysis of patients with well-differentiated to moderately differentiated NETs, disease stage, primary tumor site, histologic grade, sex, race, age, and year of diagnosis were predictors of outcome (P < .001). ConclusionWe observed increased reported incidence of NETs and increased survival durations over time, suggesting that NETs are more prevalent than previously reported. Clinicians need to be become familiar with the natural history and patterns of disease progression, which are characteristic of these tumors. 10.1200/JCO.2007.15.4377 IS - 18 JF - J Clin Oncol EP - 3072 TI - One Hundred Years After "Carcinoid": Epidemiology of and Prognostic Factors for Neuroendocrine Tumors in 35,825 Cases in the United States VL - 26 SP - 3063 KW - carcinoid AU - Yao, James AU - Hassan, Manal AU - Phan, Alexandria AU - Dagohoy, Cecile AU - Leary, Colleen AU - Mares, Jeannette AU - Abdalla, Eddie AU - Fleming, Jason AU - Vauthey, Jean-Nicolas AU - Rashid, Asif AU - Evans, Douglas PY - 2008/06/20/ UR - http://dx.doi.org/10.1200/JCO.2007.15.4377 ER -