Red cell membrane: past, present, and future Export

@article{citeulike:3680072, abstract = {As a result of natural selection driven by severe forms of malaria, 1 in 6 humans in the world, more than 1 billion people, are affected by red cell abnormalities, making them the most common of the inherited disorders. The non-nucleated red cell is unique among human cell type in that the plasma membrane, its only structural component, accounts for all of its diverse antigenic, transport, and mechanical characteristics. Our current concept of the red cell membrane envisions it as a composite structure in which a membrane envelope composed of cholesterol and phospholipids is secured to an elastic network of skeletal proteins via transmembrane proteins. Structural and functional characterization of the many constituents of the red cell membrane, in conjunction with biophysical and physiologic studies, has led to detailed description of the way in which the remarkable mechanical properties and other important characteristics of the red cells arise, and of the manner in which they fail in disease states. Current studies in this very active and exciting field are continuing to produce new and unexpected revelations on the function of the red cell membrane and thus of the cell in health and disease, and shed new light on membrane function in other diverse cell types. 10.1182/blood-2008-07-161166}, author = {Mohandas, Narla and Gallagher, Patrick G.}, citeulike-article-id = {3680072}, citeulike-linkout-0 = {http://dx.doi.org/10.1182/blood-2008-07-161166}, citeulike-linkout-1 = {http://bloodjournal.hematologylibrary.org/content/112/10/3939.abstract}, citeulike-linkout-2 = {http://bloodjournal.hematologylibrary.org/content/112/10/3939.full.pdf}, citeulike-linkout-3 = {http://bloodjournal.hematologylibrary.org/cgi/content/abstract/112/10/3939}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/18988878}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=18988878}, day = {15}, doi = {10.1182/blood-2008-07-161166}, journal = {Blood}, keywords = {rbc}, month = {November}, number = {10}, pages = {3939--3948}, posted-at = {2008-11-24 00:14:18}, priority = {2}, title = {Red cell membrane: past, present, and future}, url = {http://dx.doi.org/10.1182/blood-2008-07-161166}, volume = {112}, year = {2008} }

TY - JOUR ID - citeulike:3680072 L3 - citeulike-article-id:3680072 N2 - As a result of natural selection driven by severe forms of malaria, 1 in 6 humans in the world, more than 1 billion people, are affected by red cell abnormalities, making them the most common of the inherited disorders. The non-nucleated red cell is unique among human cell type in that the plasma membrane, its only structural component, accounts for all of its diverse antigenic, transport, and mechanical characteristics. Our current concept of the red cell membrane envisions it as a composite structure in which a membrane envelope composed of cholesterol and phospholipids is secured to an elastic network of skeletal proteins via transmembrane proteins. Structural and functional characterization of the many constituents of the red cell membrane, in conjunction with biophysical and physiologic studies, has led to detailed description of the way in which the remarkable mechanical properties and other important characteristics of the red cells arise, and of the manner in which they fail in disease states. Current studies in this very active and exciting field are continuing to produce new and unexpected revelations on the function of the red cell membrane and thus of the cell in health and disease, and shed new light on membrane function in other diverse cell types. 10.1182/blood-2008-07-161166 IS - 10 JF - Blood EP - 3948 TI - Red cell membrane: past, present, and future VL - 112 SP - 3939 KW - rbc AU - Mohandas, Narla AU - Gallagher, Patrick PY - 2008/11/15/ UR - http://dx.doi.org/10.1182/blood-2008-07-161166 ER -