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Plasma levels of atrial and brain natriuretic peptides as indicators of recovery of left ventricular systolic function after coronary artery bypass Export

European Journal of Cardio-Thoracic Surgery, Vol. 20, No. 1. (July 2001), pp. 140-146.

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Objective: The purpose of this study was to investigate the effectiveness of atrial and brain natriuretic peptides (ANP and BNP, respectively) as indicators of recovery of left ventricular (LV) function after coronary surgery. Methods: We measured the concentrations of these peptides in 31 patients with poor LV function (ejection fraction, EFResults: Pre-operatively, the plasma levels of both ANP and BNP were markedly higher in coronary patients than in normal control subjects, and strongly correlated with both EF (BNP: r=-0.8, Pr=-0.6, PBNP) and ANP ([Delta]ANP) plasma levels strongly correlated with the differences of both EF (r=-0.7, PBNP; r=-0.6, P=0.0003 vs. [Delta]ANP) and WMSI (r=0.6, P=0.002 vs. [Delta]BNP; r=0.6, P=0.04 vs. [Delta]ANP). Finally, by logistic regression analysis, BNP appeared a significant predictor of LVEF recovery after surgery. Conclusion: Plasma levels of ANP and BNP might be used in routine clinical practice as a support to echocardiography in detecting recovery of the LV function after coronary surgery.


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