Analysis of risk of bleeding complications after different doses of aspirin in 192,036 patients enrolled in 31 randomized controlled trials. Export

@article{citeulike:761425, abstract = {We sought to compare the risk of hemorrhage due to the low (<100 mg), moderate (100 to 200 mg), and high (>200 mg) doses of aspirin (acetylsalicylic acid [ASA]) in 192,036 patients enrolled in 31 clinical trials. Despite substantial differences in the reporting patterns of bleeding complications, low-dose ASA was associated with the lowest risk, and moderate doses caused a relatively high hemorrhagic event rate, especially with regard to minor, gastrointestinal, and total bleeding, and stroke. These findings should be considered when using combination antiplatelets, anticoagulant therapy, or both, with ASA, especially with the daily dose of >100 mg.}, address = {HeartDrug Research Laboratories, Towson, Maryland, USA. Heartdrug@aol.com <Heartdrug@aol.com>}, author = {Serebruany, V. L. and Steinhubl, S. R. and Berger, P. B. and Malinin, A. I. and Baggish, J. S. and Bhatt, D. L. and Topol, E. J.}, citeulike-article-id = {761425}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.amjcard.2005.01.049}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15877994}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15877994}, day = {15}, doi = {10.1016/j.amjcard.2005.01.049}, issn = {0002-9149}, journal = {Am J Cardiol}, keywords = {aas, aas-pop-bleeding}, month = {May}, number = {10}, pages = {1218--1222}, posted-at = {2006-07-16 21:30:05}, priority = {0}, title = {Analysis of risk of bleeding complications after different doses of aspirin in 192,036 patients enrolled in 31 randomized controlled trials.}, url = {http://dx.doi.org/10.1016/j.amjcard.2005.01.049}, volume = {95}, year = {2005} }

TY - JOUR ID - citeulike:761425 L3 - citeulike-article-id:761425 N2 - We sought to compare the risk of hemorrhage due to the low (<100 mg), moderate (100 to 200 mg), and high (>200 mg) doses of aspirin (acetylsalicylic acid [ASA]) in 192,036 patients enrolled in 31 clinical trials. Despite substantial differences in the reporting patterns of bleeding complications, low-dose ASA was associated with the lowest risk, and moderate doses caused a relatively high hemorrhagic event rate, especially with regard to minor, gastrointestinal, and total bleeding, and stroke. These findings should be considered when using combination antiplatelets, anticoagulant therapy, or both, with ASA, especially with the daily dose of >100 mg. IS - 10 JF - Am J Cardiol SN - 0002-9149 AD - HeartDrug Research Laboratories, Towson, Maryland, USA. Heartdrug@aol.com <Heartdrug@aol.com> EP - 1222 TI - Analysis of risk of bleeding complications after different doses of aspirin in 192,036 patients enrolled in 31 randomized controlled trials. VL - 95 SP - 1218 KW - aas KW - aas-pop-bleeding AU - Serebruany, VL AU - Steinhubl, SR AU - Berger, PB AU - Malinin, AI AU - Baggish, JS AU - Bhatt, DL AU - Topol, EJ PY - 2005/05/15/ UR - http://dx.doi.org/10.1016/j.amjcard.2005.01.049 ER -