A genomic regulatory network for development.

by: EH Davidson, JP Rast, P Oliveri, A Ransick, C Calestani, CH Yuh, T Minokawa, G Amore, V Hinman, C Arenas-Mena, O Otim, CT Brown, CB Livi, PY Lee, R Revilla, AG Rust, Z Pan, MJ Schilstra, PJ Clarke, MI Arnone, L Rowen, RA Cameron, DR McClay, L Hood, H Bolouri

Science, Vol. 295, No. 5560. (1 March 2002), pp. 1669-1678.

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Abstract

Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. Its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.

@article{citeulike:1028747, abstract = {Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. Its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.}, address = {Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. davidson@caltech.edu}, author = {Davidson, E. H. and Rast, J. P. and Oliveri, P. and Ransick, A. and Calestani, C. and Yuh, C. H. and Minokawa, T. and Amore, G. and Hinman, V. and Arenas-Mena, C. and Otim, O. and Brown, C. T. and Livi, C. B. and Lee, P. Y. and Revilla, R. and Rust, A. G. and Pan, Z. and Schilstra, M. J. and Clarke, P. J. and Arnone, M. I. and Rowen, L. and Cameron, R. A. and McClay, D. R. and Hood, L. and Bolouri, H. }, citeulike-article-id = {1028747}, doi = {10.1126/science.1069883}, issn = {1095-9203}, journal = {Science}, keywords = {development, mesc\_project, model}, month = {March}, number = {5560}, pages = {1669--1678}, posted-at = {2008-07-25 08:09:01}, priority = {4}, title = {A genomic regulatory network for development.}, url = {http://dx.doi.org/10.1126/science.1069883}, volume = {295}, year = {2002} }

RIS record

TY - JOUR ID - citeulike:1028747 L3 - citeulike-article-id:1028747 TI - A genomic regulatory network for development. JF - Science VL - 295 IS - 5560 SP - 1669 EP - 1678 AD - Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. davidson@caltech.edu SN - 1095-9203 N2 - Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. Its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time. KW - development KW - mesc_project KW - model AU - Davidson, EH AU - Rast, JP AU - Oliveri, P AU - Ransick, A AU - Calestani, C AU - Yuh, CH AU - Minokawa, T AU - Amore, G AU - Hinman, V AU - Arenas-Mena, C AU - Otim, O AU - Brown, CT AU - Livi, CB AU - Lee, PY AU - Revilla, R AU - Rust, AG AU - Pan, Z AU - Schilstra, MJ AU - Clarke, PJ AU - Arnone, MI AU - Rowen, L AU - Cameron, RA AU - McClay, DR AU - Hood, L AU - Bolouri, H PY - 2002/03/01/ UR - http://dx.doi.org/10.1126/science.1069883 ER -

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