Phagocytosis of human post-capacitated spermatozoa by macrophages Export

@article{Oren-BenaroyaKipnis2007, abstract = {Earlier studies demonstrated that macrophages phagocytize spermatozoa in the female genital tract of mammals. In spite of this phagocytosis, fecundity is not affected, raising questions of how the resulting decrease in the number of spermatozoa does not reduce the fertilization rate and of the role of this phagocytosis. We hypothesized that its role is to rid the female genital tract of spermatozoa past their fertilizing stage (post-capacitated spermatozoa). Here we examined whether, indeed, phagocytosis is restricted to post-capacitated spermatozoa. METHODSSpermatozoa were incubated for 22 h either in a medium that allows them to become capacitated and then post-capacitated, or in a medium that prevents them from acquiring these states. These sperm populations were compared for their susceptibilities to macrophage phagocytosis. RESULTSPhagocytosis was significantly higher (P << 0.001) in the sperm population containing post-capacitated spermatozoa. Vitality, motility, the acrosomal status and the proportion of capacitated cells did not affect phagocytosis. CONCLUSIONPost-capacitated spermatozoa are, probably, preferentially phagocytized by macrophages. 10.1093/humrep/dem273}, author = {Oren-Benaroya, Rony and Kipnis, Jonathan and Eisenbach, Michael}, citeulike-article-id = {3856889}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/humrep/dem273}, citeulike-linkout-1 = {http://humrep.oxfordjournals.org/cgi/content/abstract/22/11/2947}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17766922}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17766922}, day = {1}, doi = {10.1093/humrep/dem273}, journal = {Hum. Reprod.}, keywords = {oviduct-comp-model}, month = {November}, number = {11}, pages = {2947--2955}, posted-at = {2009-01-07 10:23:30}, priority = {2}, title = {Phagocytosis of human post-capacitated spermatozoa by macrophages}, url = {http://dx.doi.org/10.1093/humrep/dem273}, volume = {22}, year = {2007} }

TY - JOUR ID - Oren-BenaroyaKipnis2007 L3 - citeulike-article-id:3856889 N2 - Earlier studies demonstrated that macrophages phagocytize spermatozoa in the female genital tract of mammals. In spite of this phagocytosis, fecundity is not affected, raising questions of how the resulting decrease in the number of spermatozoa does not reduce the fertilization rate and of the role of this phagocytosis. We hypothesized that its role is to rid the female genital tract of spermatozoa past their fertilizing stage (post-capacitated spermatozoa). Here we examined whether, indeed, phagocytosis is restricted to post-capacitated spermatozoa. METHODSSpermatozoa were incubated for 22 h either in a medium that allows them to become capacitated and then post-capacitated, or in a medium that prevents them from acquiring these states. These sperm populations were compared for their susceptibilities to macrophage phagocytosis. RESULTSPhagocytosis was significantly higher (P << 0.001) in the sperm population containing post-capacitated spermatozoa. Vitality, motility, the acrosomal status and the proportion of capacitated cells did not affect phagocytosis. CONCLUSIONPost-capacitated spermatozoa are, probably, preferentially phagocytized by macrophages. 10.1093/humrep/dem273 IS - 11 JF - Hum. Reprod. EP - 2955 TI - Phagocytosis of human post-capacitated spermatozoa by macrophages VL - 22 SP - 2947 KW - oviduct-comp-model AU - Oren-Benaroya, Rony AU - Kipnis, Jonathan AU - Eisenbach, Michael PY - 2007/11/01/ UR - http://dx.doi.org/10.1093/humrep/dem273 ER -