Systems biology in systemic lupus erythematosus: Integrating genes, biology and immune function. Export

@article{citeulike:1018206, abstract = {Overactive B cells, abnormally activated T cells and inappropriate handling of cellular debris by the innate immune system are central in the pathogenesis of systemic lupus erythematosus (SLE). Genetic studies in SLE patients have unraveled allelic variations in genes encoding key molecules that control inter- and intra-cellular signaling and play a role in the abnormal handling of apoptotic material. Despite recent breakthroughs though, it is still unclear how exactly genes and environment interact to produce the characteristic immune dysregulation in SLE.}, address = {Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, 02115, USA.}, author = {Kyttaris, V. C. and Krishnan, S. and Tsokos, G. C.}, citeulike-article-id = {1018206}, citeulike-linkout-0 = {http://dx.doi.org/10.1080/08916930601061363}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17178567}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17178567}, doi = {10.1080/08916930601061363}, issn = {0891-6934}, journal = {Autoimmunity}, keywords = {ra}, month = {December}, number = {8}, pages = {705--709}, posted-at = {2006-12-28 12:17:16}, priority = {2}, title = {Systems biology in systemic lupus erythematosus: Integrating genes, biology and immune function.}, url = {http://dx.doi.org/10.1080/08916930601061363}, volume = {39}, year = {2006} }

TY - JOUR ID - citeulike:1018206 L3 - citeulike-article-id:1018206 N2 - Overactive B cells, abnormally activated T cells and inappropriate handling of cellular debris by the innate immune system are central in the pathogenesis of systemic lupus erythematosus (SLE). Genetic studies in SLE patients have unraveled allelic variations in genes encoding key molecules that control inter- and intra-cellular signaling and play a role in the abnormal handling of apoptotic material. Despite recent breakthroughs though, it is still unclear how exactly genes and environment interact to produce the characteristic immune dysregulation in SLE. IS - 8 JF - Autoimmunity SN - 0891-6934 AD - Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, 02115, USA. EP - 709 TI - Systems biology in systemic lupus erythematosus: Integrating genes, biology and immune function. VL - 39 SP - 705 KW - ra AU - Kyttaris, VC AU - Krishnan, S AU - Tsokos, GC PY - 2006/12// UR - http://dx.doi.org/10.1080/08916930601061363 ER -