Dissecting the Regulatory Circuitry of a Eukaryotic Genome Export

@article{citeulike:2514887, abstract = {Genome-wide expression analysis was used to identify genes whose expression depends on the functions of key components of the transcription initiation machinery in yeast. Components of the RNA polymerase II holoenzyme, the general transcription factor TFIID, and the SAGA chromatin modification complex were found to have roles in expression of distinct sets of genes. The results reveal an unanticipated level of regulation which is superimposed on that due to gene-specific transcription factors, a novel mechanism for coordinate regulation of specific sets of genes when cells encounter limiting nutrients, and evidence that the ultimate targets of signal transduction pathways can be identified within the initiation apparatus.}, author = {Holstege, Frank C. and Jennings, Ezra G. and Wyrick, John J. and Lee, Tong I. and Hengartner, Christoph J. and Green, Michael R. and Golub, Todd R. and Lander, Eric S. and Young, Richard A.}, citeulike-article-id = {2514887}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0092-8674(00)81641-4}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6WSN-41MBC16-M/2/ccc57b18da05cb7457a4331ce92edbe6}, day = {25}, doi = {10.1016/S0092-8674(00)81641-4}, journal = {Cell}, keywords = {cdk8, med17, med18, med6, mediator, microarray, rna-polii, saga, swisnf, tfiid, tfiie, tfiih}, month = {November}, number = {5}, pages = {717--728}, posted-at = {2008-09-19 20:46:25}, priority = {2}, title = {Dissecting the Regulatory Circuitry of a Eukaryotic Genome}, url = {http://dx.doi.org/10.1016/S0092-8674(00)81641-4}, volume = {95}, year = {1998} }

TY - JOUR ID - citeulike:2514887 L3 - citeulike-article-id:2514887 N2 - Genome-wide expression analysis was used to identify genes whose expression depends on the functions of key components of the transcription initiation machinery in yeast. Components of the RNA polymerase II holoenzyme, the general transcription factor TFIID, and the SAGA chromatin modification complex were found to have roles in expression of distinct sets of genes. The results reveal an unanticipated level of regulation which is superimposed on that due to gene-specific transcription factors, a novel mechanism for coordinate regulation of specific sets of genes when cells encounter limiting nutrients, and evidence that the ultimate targets of signal transduction pathways can be identified within the initiation apparatus. IS - 5 JF - Cell EP - 728 TI - Dissecting the Regulatory Circuitry of a Eukaryotic Genome VL - 95 SP - 717 KW - cdk8 KW - med17 KW - med18 KW - med6 KW - mediator KW - microarray KW - rna-polii KW - saga KW - swisnf KW - tfiid KW - tfiie KW - tfiih AU - Holstege, Frank AU - Jennings, Ezra AU - Wyrick, John AU - Lee, Tong AU - Hengartner, Christoph AU - Green, Michael AU - Golub, Todd AU - Lander, Eric AU - Young, Richard PY - 1998/11/25/ UR - http://dx.doi.org/10.1016/S0092-8674(00)81641-4 ER -