Modulation of Gene Expression via Disruption of NF-kappaB Signaling by a Bacterial Small Molecule Export

@article{citeulike:3025281, abstract = {The control of innate immune responses through activation of the nuclear transcription factor NF-{kappa}B is essential for the elimination of invading microbial pathogens. We showed that the bacterial N-(3-oxo-dodecanoyl) homoserine lactone (C12) selectively impairs the regulation of NF-{kappa}B functions in activated mammalian cells. The consequence is specific repression of stimulus-mediated induction of NF-{kappa}B-responsive genes encoding inflammatory cytokines and other immune regulators. These findings uncover a strategy by which C12-producing opportunistic pathogens, such as Pseudomonas aeruginosa, attenuate the innate immune system to establish and maintain local persistent infection in humans, for example, in cystic fibrosis patients. 10.1126/science.1156499}, author = {Kravchenko, Vladimir V. and Kaufmann, Gunnar F. and Mathison, John C. and Scott, David A. and Katz, Alexander Z. and Grauer, David C. and Lehmann, Mandy and Meijler, Michael M. and Janda, Kim D. and Ulevitch, Richard J.}, citeulike-article-id = {3025281}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1156499}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/321/5886/259}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18566250}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18566250}, day = {11}, doi = {10.1126/science.1156499}, journal = {Science}, keywords = {bacteria, journalclub, nf-kb, small-molecule}, month = {July}, number = {5886}, pages = {259--263}, posted-at = {2008-07-21 20:49:42}, priority = {2}, title = {Modulation of Gene Expression via Disruption of NF-{kappa}B Signaling by a Bacterial Small Molecule}, url = {http://dx.doi.org/10.1126/science.1156499}, volume = {321}, year = {2008} }

TY - JOUR ID - citeulike:3025281 L3 - citeulike-article-id:3025281 N2 - The control of innate immune responses through activation of the nuclear transcription factor NF-{kappa}B is essential for the elimination of invading microbial pathogens. We showed that the bacterial N-(3-oxo-dodecanoyl) homoserine lactone (C12) selectively impairs the regulation of NF-{kappa}B functions in activated mammalian cells. The consequence is specific repression of stimulus-mediated induction of NF-{kappa}B-responsive genes encoding inflammatory cytokines and other immune regulators. These findings uncover a strategy by which C12-producing opportunistic pathogens, such as Pseudomonas aeruginosa, attenuate the innate immune system to establish and maintain local persistent infection in humans, for example, in cystic fibrosis patients. 10.1126/science.1156499 IS - 5886 JF - Science EP - 263 TI - Modulation of Gene Expression via Disruption of NF-{kappa}B Signaling by a Bacterial Small Molecule VL - 321 SP - 259 KW - bacteria KW - journalclub KW - nf-kb KW - small-molecule AU - Kravchenko, Vladimir AU - Kaufmann, Gunnar AU - Mathison, John AU - Scott, David AU - Katz, Alexander AU - Grauer, David AU - Lehmann, Mandy AU - Meijler, Michael AU - Janda, Kim AU - Ulevitch, Richard PY - 2008/07/11/ UR - http://dx.doi.org/10.1126/science.1156499 ER -