A computational model of electrical stimulation of the retinal ganglion cell Export

@article{citeulike:3749842, abstract = {Localized retinal electrical stimulation in blind volunteers results in discrete round visual percepts corresponding to the location of the stimulating electrode. The success of such an approach to provide useful vision depends on elucidating the neuronal target of surface electrical stimulation. To determine if electrodes preferentially stimulate ganglion cells directly below them or passing fibers from distant ganglion cells, the authors developed a compartmental model for electric field stimulation of the retinal ganglion cell (RGC). In this model a RGC is stimulated by extracellular electrical fields with active. Channels and realistic cell morphology derived directly from a neuronal tracing. Three membrane models were applied: a linear passive model, a Hodgkin-Huxley model with passive dendrites (HH), and a model composed of all active compartments (FCM) with five nonlinear ion channels. Idealized monopolar point and disk stimulating electrodes were positioned above the cell, For the HH and FCM models, the position of lowest cathodal threshold to propagate an action potential was over the soma. Brief (100 /spl mu/s) cathodic stimuli were 20\% (HH with disk electrode) to 73\% (FCM with point-source) more effective over the soma than over the axon. In the passive model, the axon is preferentially stimulated versus the soma. Although it may be possible to electrically stimulate RGC's near their cell body at lower thresholds than at their axon, these differences are relatively small. Alternative explanations should be sought to explain the focal perceptions observed in previously reported patient trials.}, author = {Greenberg, R. J. and Velte, T. J. and Humayun, M. S. and Scarlatis, G. N. and De Juan, E.}, booktitle = {Biomedical Engineering, IEEE Transactions on}, citeulike-article-id = {3749842}, citeulike-linkout-0 = {http://dx.doi.org/10.1109/10.759051}, citeulike-linkout-1 = {http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=759051}, doi = {10.1109/10.759051}, journal = {Biomedical Engineering, IEEE Transactions on}, keywords = {electrical-stimulation, ganglion-cell, model, retina, stimulation, visual-system}, number = {5}, pages = {505--514}, posted-at = {2008-12-05 11:05:04}, priority = {2}, title = {A computational model of electrical stimulation of the retinal ganglion cell}, url = {http://dx.doi.org/10.1109/10.759051}, volume = {46}, year = {1999} }

TY - JOUR ID - citeulike:3749842 L3 - citeulike-article-id:3749842 N2 - Localized retinal electrical stimulation in blind volunteers results in discrete round visual percepts corresponding to the location of the stimulating electrode. The success of such an approach to provide useful vision depends on elucidating the neuronal target of surface electrical stimulation. To determine if electrodes preferentially stimulate ganglion cells directly below them or passing fibers from distant ganglion cells, the authors developed a compartmental model for electric field stimulation of the retinal ganglion cell (RGC). In this model a RGC is stimulated by extracellular electrical fields with active. Channels and realistic cell morphology derived directly from a neuronal tracing. Three membrane models were applied: a linear passive model, a Hodgkin-Huxley model with passive dendrites (HH), and a model composed of all active compartments (FCM) with five nonlinear ion channels. Idealized monopolar point and disk stimulating electrodes were positioned above the cell, For the HH and FCM models, the position of lowest cathodal threshold to propagate an action potential was over the soma. Brief (100 /spl mu/s) cathodic stimuli were 20% (HH with disk electrode) to 73% (FCM with point-source) more effective over the soma than over the axon. In the passive model, the axon is preferentially stimulated versus the soma. Although it may be possible to electrically stimulate RGC's near their cell body at lower thresholds than at their axon, these differences are relatively small. Alternative explanations should be sought to explain the focal perceptions observed in previously reported patient trials. IS - 5 JF - Biomedical Engineering, IEEE Transactions on EP - 514 TI - A computational model of electrical stimulation of the retinal ganglion cell VL - 46 T2 - Biomedical Engineering, IEEE Transactions on SP - 505 KW - electrical-stimulation KW - ganglion-cell KW - model KW - retina KW - stimulation KW - visual-system AU - Greenberg, RJ AU - Velte, TJ AU - Humayun, MS AU - Scarlatis, GN AU - De Juan, E PY - 1999/// UR - http://dx.doi.org/10.1109/10.759051 ER -