Electrically Evoked Responses in Onset Chopper Neurons in Guinea Pig Cochlear Nucleus Export

@article{citeulike:4233041, abstract = {Extracellular recordings were obtained from single cochlear nucleus neurons in guinea pigs anesthetized with Nembutal and Hypnorm. Neurons were classified by their spontaneous firing rates and responses to acoustic stimuli. In addition, electrical shocks were applied to the midline at the level of the IVth ventricle and spike responses were recorded. Spikes were evoked by shocks only in neurons that were classified as onset choppers (Oc). The shock-evoked spikes could be extinguished by acoustically evoked action potentials in the same neurons. In roughly 30\% of the sample of Oc neurons, quantitative aspects of the timing of this extinction were not compatible with the shock-evoked spike being antidromically conducted from Oc output axons. Together with the presence of temporal jitter at high shock rates, the data suggest the possibility that at least some of the shock-evoked spikes may be generated by excitatory synaptic input to the Oc neurons, most likely from the collaterals of the medial olivocochlear system (MOCS), whose axons pass close to the floor of the IVth ventricle. This excitatory synaptic input may operate to modulate the activity of Oc neurons in addition to MOCS actions in the auditory periphery. 10.1152/jn.01148.2006}, author = {Mulders, Wilhelmina H. and Harvey, Alan R. and Robertson, Donald}, citeulike-article-id = {4233041}, citeulike-linkout-0 = {http://dx.doi.org/10.1152/jn.01148.2006}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17329623}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17329623}, day = {1}, doi = {10.1152/jn.01148.2006}, journal = {J Neurophysiol}, keywords = {chopper, cn, d-stellate, electrical-stimulation, guinea, neuron, onset, pig, stellate}, month = {May}, number = {5}, pages = {3288--3297}, posted-at = {2009-03-27 17:24:16}, priority = {2}, title = {Electrically Evoked Responses in Onset Chopper Neurons in Guinea Pig Cochlear Nucleus}, url = {http://dx.doi.org/10.1152/jn.01148.2006}, volume = {97}, year = {2007} }

TY - JOUR ID - citeulike:4233041 L3 - citeulike-article-id:4233041 N2 - Extracellular recordings were obtained from single cochlear nucleus neurons in guinea pigs anesthetized with Nembutal and Hypnorm. Neurons were classified by their spontaneous firing rates and responses to acoustic stimuli. In addition, electrical shocks were applied to the midline at the level of the IVth ventricle and spike responses were recorded. Spikes were evoked by shocks only in neurons that were classified as onset choppers (Oc). The shock-evoked spikes could be extinguished by acoustically evoked action potentials in the same neurons. In roughly 30% of the sample of Oc neurons, quantitative aspects of the timing of this extinction were not compatible with the shock-evoked spike being antidromically conducted from Oc output axons. Together with the presence of temporal jitter at high shock rates, the data suggest the possibility that at least some of the shock-evoked spikes may be generated by excitatory synaptic input to the Oc neurons, most likely from the collaterals of the medial olivocochlear system (MOCS), whose axons pass close to the floor of the IVth ventricle. This excitatory synaptic input may operate to modulate the activity of Oc neurons in addition to MOCS actions in the auditory periphery. 10.1152/jn.01148.2006 IS - 5 JF - J Neurophysiol EP - 3297 TI - Electrically Evoked Responses in Onset Chopper Neurons in Guinea Pig Cochlear Nucleus VL - 97 SP - 3288 KW - chopper KW - cn KW - d-stellate KW - electrical-stimulation KW - guinea KW - neuron KW - onset KW - pig KW - stellate AU - Mulders, Wilhelmina AU - Harvey, Alan AU - Robertson, Donald PY - 2007/05/01/ UR - http://dx.doi.org/10.1152/jn.01148.2006 ER -