The kinetics of the response to glutamate and kainate in neurons of the avian cochlear nucleus Export

@article{citeulike:5280673, abstract = {Neurons in the nucleus magnocellularis (nMAG) of the chicken precisely transmit auditory nerve activity via glutamatergic synapses. Using techniques for rapid application of solutions, we have explored the properties of CNQX-sensitive glutamate receptors in whole cells and outside-out patches from the nMAG. Glutamate-evoked current in patches desensitized biphasically to less than 1\% of the peak current, with a fast time constant of 960 ¼s at 22°C, decreasing to 570 ¼s at 33°C. Dose-response studies using kainate indicated that at least two agonist molecules bind to gate the channel. We propose a kinetic model that quantitatively describes our experimental observations. The rapid kinetics of this receptor are well suited to allow phase locking of synaptic signals to auditory stimuli.}, author = {Raman, Indira M. and Trussell, Laurence O.}, citeulike-article-id = {5280673}, citeulike-linkout-0 = {http://www.cell.com/neuron/abstract/0896-6273(92)90232-3}, day = {1}, keywords = {calyx, constant, endbulb, glutamate, held, of, receptor, temperature, time}, month = {July}, number = {1}, pages = {173--186}, posted-at = {2009-07-27 12:31:25}, priority = {2}, title = {The kinetics of the response to glutamate and kainate in neurons of the avian cochlear nucleus}, url = {http://www.cell.com/neuron/abstract/0896-6273(92)90232-3}, volume = {9}, year = {1992} }

TY - JOUR ID - citeulike:5280673 L3 - citeulike-article-id:5280673 N2 - Neurons in the nucleus magnocellularis (nMAG) of the chicken precisely transmit auditory nerve activity via glutamatergic synapses. Using techniques for rapid application of solutions, we have explored the properties of CNQX-sensitive glutamate receptors in whole cells and outside-out patches from the nMAG. Glutamate-evoked current in patches desensitized biphasically to less than 1% of the peak current, with a fast time constant of 960 ¼s at 22°C, decreasing to 570 ¼s at 33°C. Dose-response studies using kainate indicated that at least two agonist molecules bind to gate the channel. We propose a kinetic model that quantitatively describes our experimental observations. The rapid kinetics of this receptor are well suited to allow phase locking of synaptic signals to auditory stimuli. IS - 1 EP - 186 TI - The kinetics of the response to glutamate and kainate in neurons of the avian cochlear nucleus VL - 9 SP - 173 KW - calyx KW - constant KW - endbulb KW - glutamate KW - held KW - of KW - receptor KW - temperature KW - time AU - Raman, Indira AU - Trussell, Laurence PY - 1992/07/01/ UR - http://www.cell.com/neuron/abstract/0896-6273(92)90232-3 ER -