Dynamic effects of antibody-dependent enhancement on the fitness of viruses. Export

@article{citeulike:430066, abstract = {Antibody-dependent enhancement (ADE), a phenomenon in which viral replication is increased rather than decreased by immune sera, has been observed in vitro for a large number of viruses of public health importance, including flaviviruses, coronaviruses, and retroviruses. The most striking in vivo example of ADE in humans is dengue hemorrhagic fever, a disease in which ADE is thought to increase the severity of clinical manifestations of dengue virus infection by increasing virus replication. We examine the epidemiological impact of ADE on the prevalence and persistence of viral serotypes. Using a dynamical system model of n cocirculating dengue serotypes, we find that ADE may provide a competitive advantage to those serotypes that undergo enhancement compared with those that do not, and that this advantage increases with increasing numbers of cocirculating serotypes. Paradoxically, there are limits to the selective advantage provided by increasing levels of ADE, because greater levels of enhancement induce large amplitude oscillations in incidence of all dengue virus infections, threatening the persistence of both the enhanced and nonenhanced serotypes. Although the models presented here are specifically designed for dengue, our results are applicable to any epidemiological system in which partial immunity increases pathogen replication rates. Our results suggest that enhancement is most advantageous in settings where multiple serotypes circulate and where a large host population is available to support pathogen persistence during the deep troughs of ADE-induced large amplitude oscillations of virus replication.}, address = {Department of International Health, Bloomberg School of Public Health, The Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA.}, author = {Cummings, D. A. and Schwartz, I. B. and Billings, L. and Shaw, L. B. and Burke, D. S.}, citeulike-article-id = {430066}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0507320102}, citeulike-linkout-1 = {http://www.pnas.org/content/102/42/15259.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/102/42/15259.full.pdf}, citeulike-linkout-3 = {http://www.pnas.org/cgi/content/abstract/102/42/15259}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/16217017}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=16217017}, comment = {[words] sera (<pl. serum): 血清 :::: serotype : 血清型 :::: ADE : "A non-neutralizing antibody from previous heterotypic dengue infection enhances the growth of virus" :::: viremia: ウイルス血症 ---=note-separator=--- [notes] ADE is thought to increase the viral load, not susceptibility. Therefore increasing the transimissibility of secondary infections, denoted by ADE factor φ(1 to 5). SIR model. "evolutionary tradeoff between the advantage (=increased transmissability) and the disadvantages (=increased probability of extinction at high levels of ADE enhancement)."}, day = {18}, doi = {10.1073/pnas.0507320102}, issn = {0027-8424}, journal = {Proc Natl Acad Sci U S A}, keywords = {05matheco25\_theoretic, adaptive, cat\_population\_biology, dengue, trade-off}, month = {October}, number = {42}, pages = {15259--15264}, posted-at = {2005-12-07 16:21:18}, priority = {0}, title = {Dynamic effects of antibody-dependent enhancement on the fitness of viruses.}, url = {http://dx.doi.org/10.1073/pnas.0507320102}, volume = {102}, year = {2005} }

TY - JOUR ID - citeulike:430066 L3 - citeulike-article-id:430066 N2 - Antibody-dependent enhancement (ADE), a phenomenon in which viral replication is increased rather than decreased by immune sera, has been observed in vitro for a large number of viruses of public health importance, including flaviviruses, coronaviruses, and retroviruses. The most striking in vivo example of ADE in humans is dengue hemorrhagic fever, a disease in which ADE is thought to increase the severity of clinical manifestations of dengue virus infection by increasing virus replication. We examine the epidemiological impact of ADE on the prevalence and persistence of viral serotypes. Using a dynamical system model of n cocirculating dengue serotypes, we find that ADE may provide a competitive advantage to those serotypes that undergo enhancement compared with those that do not, and that this advantage increases with increasing numbers of cocirculating serotypes. Paradoxically, there are limits to the selective advantage provided by increasing levels of ADE, because greater levels of enhancement induce large amplitude oscillations in incidence of all dengue virus infections, threatening the persistence of both the enhanced and nonenhanced serotypes. Although the models presented here are specifically designed for dengue, our results are applicable to any epidemiological system in which partial immunity increases pathogen replication rates. Our results suggest that enhancement is most advantageous in settings where multiple serotypes circulate and where a large host population is available to support pathogen persistence during the deep troughs of ADE-induced large amplitude oscillations of virus replication. IS - 42 JF - Proc Natl Acad Sci U S A SN - 0027-8424 AD - Department of International Health, Bloomberg School of Public Health, The Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA. EP - 15264 TI - Dynamic effects of antibody-dependent enhancement on the fitness of viruses. VL - 102 SP - 15259 KW - 05matheco25_theoretic KW - adaptive KW - cat_population_biology KW - dengue KW - trade-off N1 - [words] sera (<pl. serum): 血清 :::: serotype : 血清型 :::: ADE : "A non-neutralizing antibody from previous heterotypic dengue infection enhances the growth of virus" :::: viremia: ウイルス血症 N1 - [notes] ADE is thought to increase the viral load, not susceptibility. Therefore increasing the transimissibility of secondary infections, denoted by ADE factor φ(1 to 5). SIR model. "evolutionary tradeoff between the advantage (=increased transmissability) and the disadvantages (=increased probability of extinction at high levels of ADE enhancement)." AU - Cummings, DA AU - Schwartz, IB AU - Billings, L AU - Shaw, LB AU - Burke, DS PY - 2005/10/18/ UR - http://dx.doi.org/10.1073/pnas.0507320102 ER -