TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment Export

@article{citeulike:3125067, abstract = {Summary Adult hippocampal neurogenesis is stimulated by chronic administration of antidepressants (ADs) and by voluntary exercise. Neural progenitor cells (NPCs) in the dentate gyrus (DG) that are capable of continuous proliferation and neuronal differentiation are the source of such structural plasticity. Here we report that mice lacking the receptor tyrosine kinase TrkB in hippocampal NPCs have impaired proliferation and neurogenesis. When exposed to chronic ADs or wheel-running, no increase in proliferation or neurogenesis is observed. Ablation of TrkB also renders these mice behaviorally insensitive to antidepressive treatment in depression- and anxiety-like paradigms. In contrast, mice lacking TrkB only in differentiated DG neurons display typical neurogenesis and respond normally to chronic ADs. Thus, our data establish an essential cell-autonomous role for TrkB in regulating hippocampal neurogenesis and behavioral sensitivity to antidepressive treatments, and support the notion that impairment of the neurogenic niche is an etiological factor for refractory responses to an antidepressive regimen.}, author = {Li, Yun and Luikart, Bryan W. and Birnbaum, Shari and Chen, Jian and Kwon, Chang-Hyuk and Kernie, Steven G. and Bassel-Duby, Rhonda and Parada, Luis F.}, citeulike-article-id = {3125067}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuron.2008.06.023}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0896627308005412}, citeulike-linkout-2 = {http://www.sciencedirect.com/science/article/B6WSS-4T6MHFJ-9/2/f5807d10a99a548ece3aabd45ce0ff0f}, day = {14}, doi = {10.1016/j.neuron.2008.06.023}, journal = {Neuron}, keywords = {antidepressants, facs}, month = {August}, number = {3}, pages = {399--412}, posted-at = {2009-05-11 13:06:27}, priority = {3}, title = {TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment}, url = {http://dx.doi.org/10.1016/j.neuron.2008.06.023}, volume = {59}, year = {2008} }

TY - JOUR ID - citeulike:3125067 L3 - citeulike-article-id:3125067 N2 - Summary Adult hippocampal neurogenesis is stimulated by chronic administration of antidepressants (ADs) and by voluntary exercise. Neural progenitor cells (NPCs) in the dentate gyrus (DG) that are capable of continuous proliferation and neuronal differentiation are the source of such structural plasticity. Here we report that mice lacking the receptor tyrosine kinase TrkB in hippocampal NPCs have impaired proliferation and neurogenesis. When exposed to chronic ADs or wheel-running, no increase in proliferation or neurogenesis is observed. Ablation of TrkB also renders these mice behaviorally insensitive to antidepressive treatment in depression- and anxiety-like paradigms. In contrast, mice lacking TrkB only in differentiated DG neurons display typical neurogenesis and respond normally to chronic ADs. Thus, our data establish an essential cell-autonomous role for TrkB in regulating hippocampal neurogenesis and behavioral sensitivity to antidepressive treatments, and support the notion that impairment of the neurogenic niche is an etiological factor for refractory responses to an antidepressive regimen. IS - 3 JF - Neuron EP - 412 TI - TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment VL - 59 SP - 399 KW - antidepressants KW - facs AU - Li, Yun AU - Luikart, Bryan AU - Birnbaum, Shari AU - Chen, Jian AU - Kwon, Chang-Hyuk AU - Kernie, Steven AU - Bassel-Duby, Rhonda AU - Parada, Luis PY - 2008/08/14/ UR - http://dx.doi.org/10.1016/j.neuron.2008.06.023 ER -