Adenosine A(2A) receptors and their role in drug addiction. Export

@article{citeulike:3471605, abstract = {The specific events between initial presumably manageable drug intake and the development of a drug-addicted state are not yet known. Drugs of abuse have varying mechanisms of action that create a complex pattern of behaviour related to drug consumption, drug-seeking, withdrawal and relapse. The neuromodulator adenosine has been shown to play a role in reward-related behaviour, both as an independent mediator and via interactions of adenosine receptors with other receptors. Adenosine levels are elevated upon exposure to drugs of abuse and adenosine A(2A) receptors are enriched in brain nuclei known for their involvement in the processing of drug-related reinforcement processing. A(2A) receptors are found in receptor clusters with dopamine and glutamate receptors. A(2A) receptors are thus ideally situated to influence the signalling of neurotransmitters relevant in the neuronal responses and plasticity that underlie the development of drug taking and drug-seeking behaviour. In this review, we present evidence for the role of adenosine and A(2A) receptors in drug addiction, thereby providing support for current efforts aimed at developing drug therapies to combat substance abuse that target adenosine signalling via A(2A) receptors.}, author = {Brown, R. M. and Short, J. L.}, citeulike-article-id = {3471605}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/18957161}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=18957161}, issn = {0022-3573}, journal = {The Journal of pharmacy and pharmacology}, keywords = {a2a, addiction}, month = {November}, number = {11}, pages = {1409--1430}, posted-at = {2008-11-01 08:48:52}, priority = {2}, title = {Adenosine A(2A) receptors and their role in drug addiction.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18957161}, volume = {60}, year = {2008} }

TY - JOUR ID - citeulike:3471605 L3 - citeulike-article-id:3471605 N2 - The specific events between initial presumably manageable drug intake and the development of a drug-addicted state are not yet known. Drugs of abuse have varying mechanisms of action that create a complex pattern of behaviour related to drug consumption, drug-seeking, withdrawal and relapse. The neuromodulator adenosine has been shown to play a role in reward-related behaviour, both as an independent mediator and via interactions of adenosine receptors with other receptors. Adenosine levels are elevated upon exposure to drugs of abuse and adenosine A(2A) receptors are enriched in brain nuclei known for their involvement in the processing of drug-related reinforcement processing. A(2A) receptors are found in receptor clusters with dopamine and glutamate receptors. A(2A) receptors are thus ideally situated to influence the signalling of neurotransmitters relevant in the neuronal responses and plasticity that underlie the development of drug taking and drug-seeking behaviour. In this review, we present evidence for the role of adenosine and A(2A) receptors in drug addiction, thereby providing support for current efforts aimed at developing drug therapies to combat substance abuse that target adenosine signalling via A(2A) receptors. IS - 11 JF - The Journal of pharmacy and pharmacology SN - 0022-3573 EP - 1430 TI - Adenosine A(2A) receptors and their role in drug addiction. VL - 60 SP - 1409 KW - a2a KW - addiction AU - Brown, RM AU - Short, JL PY - 2008/11// UR - http://view.ncbi.nlm.nih.gov/pubmed/18957161 ER -