A cAMP pathway underlying reward prediction in associative learning. Export

@article{citeulike:3471622, abstract = {In associative learning, animals learn to associate external cues or their own actions with appetitive or aversive outcomes. Although the dopamine (DA) system and the striatum/nucleus accumbens have been implicated in both the pavlovian and instrumental form of associative learning, whether specific neuronal signaling mechanisms underlie one form or the other is unknown. Here, we report that the striatum-enriched isoform of adenylyl cyclase (AC), AC5, is selectively required for appetitive pavlovian learning. Mice with genetic deletion of AC5 (AC5KO) acquired instrumental responding yet were unable to use cues that predicted reward delivery. The specificity of this deficit was confirmed by an inability of AC5KO mice to learn a simple appetitive pavlovian conditioning task. Conversely, AC5KO mice showed intact aversive pavlovian learning, suggesting the deficit was specific for learning about appetitive outcomes. Our results suggest that AC5 is a critical component of DA-dependent strengthening of stimulus-reward contingencies.}, author = {Kheirbek, M. A. and Beeler, J. A. and Ishikawa, Y. and Zhuang, X.}, citeulike-article-id = {3471622}, citeulike-linkout-0 = {http://dx.doi.org/10.1523/JNEUROSCI.4115-08.2008}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18971482}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18971482}, day = {29}, doi = {10.1523/JNEUROSCI.4115-08.2008}, issn = {1529-2401}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, keywords = {dopamine, learning, striatum}, month = {October}, number = {44}, pages = {11401--11408}, posted-at = {2008-11-01 09:24:37}, priority = {4}, title = {A cAMP pathway underlying reward prediction in associative learning.}, url = {http://dx.doi.org/10.1523/JNEUROSCI.4115-08.2008}, volume = {28}, year = {2008} }

TY - JOUR ID - citeulike:3471622 L3 - citeulike-article-id:3471622 N2 - In associative learning, animals learn to associate external cues or their own actions with appetitive or aversive outcomes. Although the dopamine (DA) system and the striatum/nucleus accumbens have been implicated in both the pavlovian and instrumental form of associative learning, whether specific neuronal signaling mechanisms underlie one form or the other is unknown. Here, we report that the striatum-enriched isoform of adenylyl cyclase (AC), AC5, is selectively required for appetitive pavlovian learning. Mice with genetic deletion of AC5 (AC5KO) acquired instrumental responding yet were unable to use cues that predicted reward delivery. The specificity of this deficit was confirmed by an inability of AC5KO mice to learn a simple appetitive pavlovian conditioning task. Conversely, AC5KO mice showed intact aversive pavlovian learning, suggesting the deficit was specific for learning about appetitive outcomes. Our results suggest that AC5 is a critical component of DA-dependent strengthening of stimulus-reward contingencies. IS - 44 JF - The Journal of neuroscience : the official journal of the Society for Neuroscience SN - 1529-2401 EP - 11408 TI - A cAMP pathway underlying reward prediction in associative learning. VL - 28 SP - 11401 KW - dopamine KW - learning KW - striatum AU - Kheirbek, MA AU - Beeler, JA AU - Ishikawa, Y AU - Zhuang, X PY - 2008/10/29/ UR - http://dx.doi.org/10.1523/JNEUROSCI.4115-08.2008 ER -