Glutamate and dopamine dysregulation in schizophrenia--a synthesis and selective review. Export

@article{citeulike:4034676, abstract = {The dopamine hypothesis of schizophrenia is the principal explanatory model of antipsychotic drug action. Recent discoveries extend our understanding of the neurochemistry of schizophrenia, with increasing evidence of dysfunction in glutamate and GABA as well as dopamine systems. In this review, we study the evidence for dopaminergic dysfunction in schizophrenia, drawing data from neurochemical imaging studies. We also review the NMDA receptor hypofunction hypothesis of schizophrenia as a supplementary explanatory model for the illness. We examine predictions made by the NMDA receptor hypofunction hypothesis and consider how they fit with current neurochemical findings in patients and animal models. We consider the case for glutamatergic excitotoxicity as a key process in the development and progression of schizophrenia, and suggest ways in which glutamate and dopamine dysregulation may interact in the condition.}, author = {Stone, J. M. and Morrison, P. D. and Pilowsky, L. S.}, citeulike-article-id = {4034676}, citeulike-linkout-0 = {http://dx.doi.org/10.1177/0269881106073126}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17259207}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17259207}, doi = {10.1177/0269881106073126}, issn = {0269-8811}, journal = {Journal of psychopharmacology (Oxford, England)}, keywords = {dopamine, glutamate, schizophrenia}, month = {June}, number = {4}, pages = {440--452}, posted-at = {2009-02-11 12:11:35}, priority = {2}, title = {Glutamate and dopamine dysregulation in schizophrenia--a synthesis and selective review.}, url = {http://dx.doi.org/10.1177/0269881106073126}, volume = {21}, year = {2007} }

TY - JOUR ID - citeulike:4034676 L3 - citeulike-article-id:4034676 N2 - The dopamine hypothesis of schizophrenia is the principal explanatory model of antipsychotic drug action. Recent discoveries extend our understanding of the neurochemistry of schizophrenia, with increasing evidence of dysfunction in glutamate and GABA as well as dopamine systems. In this review, we study the evidence for dopaminergic dysfunction in schizophrenia, drawing data from neurochemical imaging studies. We also review the NMDA receptor hypofunction hypothesis of schizophrenia as a supplementary explanatory model for the illness. We examine predictions made by the NMDA receptor hypofunction hypothesis and consider how they fit with current neurochemical findings in patients and animal models. We consider the case for glutamatergic excitotoxicity as a key process in the development and progression of schizophrenia, and suggest ways in which glutamate and dopamine dysregulation may interact in the condition. IS - 4 JF - Journal of psychopharmacology (Oxford, England) SN - 0269-8811 EP - 452 TI - Glutamate and dopamine dysregulation in schizophrenia--a synthesis and selective review. VL - 21 SP - 440 KW - dopamine KW - glutamate KW - schizophrenia AU - Stone, JM AU - Morrison, PD AU - Pilowsky, LS PY - 2007/06// UR - http://dx.doi.org/10.1177/0269881106073126 ER -