mGluR5 has a critical role in inhibitory learning. Export

@article{citeulike:4222170, abstract = {The mechanisms that contribute to the extinction of previously acquired memories are not well understood. These processes, often referred to as inhibitory learning, are thought to be parallel learning mechanisms that require a reacquisition of new information and suppression of previously acquired experiences in order to adapt to novel situations. Using newly generated metabotropic glutamate receptor 5 (mGluR5) knock-out mice, we investigated the role of mGluR5 in the acquisition and reversal of an associative conditioned task and a spatial reference task. We found that acquisition of fear conditioning is partially impaired in mice lacking mGluR5. More markedly, we found that extinction of both contextual and auditory fear was completely abolished in mGluR5 knock-out mice. In the Morris Water Maze test (MWM), mGluR5 knock-out mice exhibited mild deficits in the rate of acquisition of the regular water maze task, but again had significant deficits in the reversal task, despite overall spatial memory being intact. Together, these results demonstrate that mGluR5 is critical to the function of neural circuits that are required for inhibitory learning mechanisms, and suggest that targeting metabotropic receptors may be useful in treating psychiatric disorders in which aversive memories are inappropriately retained.}, author = {Xu, Jian and Zhu, Yongling and Contractor, Anis and Heinemann, Stephen F.}, citeulike-article-id = {4222170}, citeulike-linkout-0 = {http://dx.doi.org/10.1523/JNEUROSCI.5716-08.2009}, citeulike-linkout-1 = {http://www.jneurosci.org/cgi/content/abstract/29/12/3676}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19321764}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19321764}, day = {25}, doi = {10.1523/JNEUROSCI.5716-08.2009}, issn = {1529-2401}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, keywords = {flox, learning, mglur5}, month = {March}, number = {12}, pages = {3676--3684}, posted-at = {2009-04-07 14:48:46}, priority = {5}, title = {mGluR5 has a critical role in inhibitory learning.}, url = {http://dx.doi.org/10.1523/JNEUROSCI.5716-08.2009}, volume = {29}, year = {2009} }

TY - JOUR ID - citeulike:4222170 L3 - citeulike-article-id:4222170 N2 - The mechanisms that contribute to the extinction of previously acquired memories are not well understood. These processes, often referred to as inhibitory learning, are thought to be parallel learning mechanisms that require a reacquisition of new information and suppression of previously acquired experiences in order to adapt to novel situations. Using newly generated metabotropic glutamate receptor 5 (mGluR5) knock-out mice, we investigated the role of mGluR5 in the acquisition and reversal of an associative conditioned task and a spatial reference task. We found that acquisition of fear conditioning is partially impaired in mice lacking mGluR5. More markedly, we found that extinction of both contextual and auditory fear was completely abolished in mGluR5 knock-out mice. In the Morris Water Maze test (MWM), mGluR5 knock-out mice exhibited mild deficits in the rate of acquisition of the regular water maze task, but again had significant deficits in the reversal task, despite overall spatial memory being intact. Together, these results demonstrate that mGluR5 is critical to the function of neural circuits that are required for inhibitory learning mechanisms, and suggest that targeting metabotropic receptors may be useful in treating psychiatric disorders in which aversive memories are inappropriately retained. IS - 12 JF - The Journal of neuroscience : the official journal of the Society for Neuroscience SN - 1529-2401 EP - 3684 TI - mGluR5 has a critical role in inhibitory learning. VL - 29 SP - 3676 KW - flox KW - learning KW - mglur5 AU - Xu, Jian AU - Zhu, Yongling AU - Contractor, Anis AU - Heinemann, Stephen PY - 2009/03/25/ UR - http://dx.doi.org/10.1523/JNEUROSCI.5716-08.2009 ER -