Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity. Export

@article{citeulike:5043026, abstract = {A complex chain of intracellular signaling events, critically important in motor control, is activated by the stimulation of D1-like dopamine (DA) receptors in striatal neurons. At corticostriatal synapses on medium spiny neurons, we provide evidence that the D1-like receptor-dependent activation of DA and cyclic adenosine 3',5' monophosphate-regulated phosphoprotein 32 kDa is a crucial step for the induction of both long-term depression (LTD) and long-term potentiation (LTP), two opposing forms of synaptic plasticity. In addition, formation of LTD and LTP requires the activation of protein kinase G and protein kinase A, respectively, in striatal projection neurons. These kinases appear to be stimulated by the activation of D1-like receptors in distinct neuronal populations.}, author = {Calabresi, P. and Gubellini, P. and Centonze, D. and Picconi, B. and Bernardi, G. and Chergui, K. and Svenningsson, P. and Fienberg, A. A. and Greengard, P.}, citeulike-article-id = {5043026}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11069952}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11069952}, comment = {Calabresi 2000 DARPP-32 is necessary for both LTD and LTP in striatum (absent in K.O.) * MSN >90\% of the striatal cells and only output type * DA receptors both on MSN and interneurons (!! D1-miR-Grm5) * LTP is NMDA, Ca and PKA x LTD is AMPA, * D1 blocker to MSN - LTP blocked X to bath - both LTP and LTD * LTD induced by 1) HSF of corticostriatal afferents OR 2) Zaprinast OR 3) SNAP is DARPP-32 dependent * LTP - M1/PKC (NMDA mediated) X LTD (interneurons) - NO/cGMP/PKG, DARPP-32 is needed for this effect * D1 lies upstream NO/cGMP/PKG * L-type Ca channels are not involved i D1/cAMP/PKA/DARPP-32/PP-1 pathway * DARPP-32 is phosporylated by PKA on Ser897 X by PKC on Ser890 * DARPP-32 K.O. no major behavioral phenotype Pharmacology * SNAP - NO donor * Zaprinast - cGMP-phosphodiesterase inhibitor = increase cGMP level }, day = {15}, issn = {1529-2401}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, keywords = {darpp-32, ltd, ltp, msn}, month = {November}, number = {22}, pages = {8443--8451}, posted-at = {2009-07-02 17:23:46}, priority = {0}, title = {Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11069952}, volume = {20}, year = {2000} }

TY - JOUR ID - citeulike:5043026 L3 - citeulike-article-id:5043026 N2 - A complex chain of intracellular signaling events, critically important in motor control, is activated by the stimulation of D1-like dopamine (DA) receptors in striatal neurons. At corticostriatal synapses on medium spiny neurons, we provide evidence that the D1-like receptor-dependent activation of DA and cyclic adenosine 3',5' monophosphate-regulated phosphoprotein 32 kDa is a crucial step for the induction of both long-term depression (LTD) and long-term potentiation (LTP), two opposing forms of synaptic plasticity. In addition, formation of LTD and LTP requires the activation of protein kinase G and protein kinase A, respectively, in striatal projection neurons. These kinases appear to be stimulated by the activation of D1-like receptors in distinct neuronal populations. IS - 22 JF - The Journal of neuroscience : the official journal of the Society for Neuroscience SN - 1529-2401 EP - 8451 TI - Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity. VL - 20 SP - 8443 KW - darpp-32 KW - ltd KW - ltp KW - msn N1 - Calabresi 2000 DARPP-32 is necessary for both LTD and LTP in striatum (absent in K.O.) * MSN >90% of the striatal cells and only output type * DA receptors both on MSN and interneurons (!! D1-miR-Grm5) * LTP is NMDA, Ca and PKA x LTD is AMPA, * D1 blocker to MSN - LTP blocked X to bath - both LTP and LTD * LTD induced by 1) HSF of corticostriatal afferents OR 2) Zaprinast OR 3) SNAP is DARPP-32 dependent * LTP - M1/PKC (NMDA mediated) X LTD (interneurons) - NO/cGMP/PKG, DARPP-32 is needed for this effect * D1 lies upstream NO/cGMP/PKG * L-type Ca channels are not involved i D1/cAMP/PKA/DARPP-32/PP-1 pathway * DARPP-32 is phosporylated by PKA on Ser897 X by PKC on Ser890 * DARPP-32 K.O. no major behavioral phenotype Pharmacology * SNAP - NO donor * Zaprinast - cGMP-phosphodiesterase inhibitor = increase cGMP level AU - Calabresi, P AU - Gubellini, P AU - Centonze, D AU - Picconi, B AU - Bernardi, G AU - Chergui, K AU - Svenningsson, P AU - Fienberg, AA AU - Greengard, P PY - 2000/11/15/ UR - http://view.ncbi.nlm.nih.gov/pubmed/11069952 ER -