Developments in the management of autosomal dominant polycystic kidney disease.

@article{citeulike:3181265, abstract = {Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent life- threatening, hereditary disease. ADPKD is more common than sickle cell anemia, cystic fibrosis, muscular dystrophy, hemophilia, Down's syndrome, and Huntington's disease combined. ADPKD is a multisystemic disorder characterized by the progressive development of renal cysts and marked renal enlargement. Structural and functional renal deterioration occurs in ADPKD patients and is the fourth leading cause of end-stage renal disease (ESRD) in adults. Aside from the renal manifestations, extrarenal structural abnormalities, such as liver cysts, cardiovascular abnormalities, and intracranial aneurysms may lead to morbidity and mortality. Recent studies have identified prognostic factors for progressive renal impairment including gender, race, age, proteinuria, hematuria, hypertension and increased left ventricular mass index (LVMI). Early diagnosis and better understanding of the pathophysiology of the disease provides the opportunity to aggressivly treat hypertension with renin-angiotensin-aldosterone system inhibitors and thereby potentially reduce LVMI, prevent cardiovascular morbidity and mortality and slow progression of the renal disease.}, address = {Department of Medicine, Health Sciences Center, University of Colorado School of Medicine Denver, CO 80262, USA.}, author = {Masoumi, A. and Reed-Gitomer, B. and Kelleher, C. and Bekheirnia, M. R. and Schrier, R. W.}, citeulike-article-id = {3181265}, issn = {1176-6336}, journal = {Therapeutics and clinical risk management}, keywords = {sicklecell}, month = {April}, number = {2}, pages = {393--407}, posted-at = {2008-09-02 10:54:35}, priority = {2}, title = {Developments in the management of autosomal dominant polycystic kidney disease.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18728845}, volume = {4}, year = {2008} }

TY - JOUR ID - citeulike:3181265 L3 - citeulike-article-id:3181265 N2 - Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent life- threatening, hereditary disease. ADPKD is more common than sickle cell anemia, cystic fibrosis, muscular dystrophy, hemophilia, Down's syndrome, and Huntington's disease combined. ADPKD is a multisystemic disorder characterized by the progressive development of renal cysts and marked renal enlargement. Structural and functional renal deterioration occurs in ADPKD patients and is the fourth leading cause of end-stage renal disease (ESRD) in adults. Aside from the renal manifestations, extrarenal structural abnormalities, such as liver cysts, cardiovascular abnormalities, and intracranial aneurysms may lead to morbidity and mortality. Recent studies have identified prognostic factors for progressive renal impairment including gender, race, age, proteinuria, hematuria, hypertension and increased left ventricular mass index (LVMI). Early diagnosis and better understanding of the pathophysiology of the disease provides the opportunity to aggressivly treat hypertension with renin-angiotensin-aldosterone system inhibitors and thereby potentially reduce LVMI, prevent cardiovascular morbidity and mortality and slow progression of the renal disease. IS - 2 JF - Therapeutics and clinical risk management SN - 1176-6336 AD - Department of Medicine, Health Sciences Center, University of Colorado School of Medicine Denver, CO 80262, USA. EP - 407 TI - Developments in the management of autosomal dominant polycystic kidney disease. VL - 4 SP - 393 KW - sicklecell AU - Masoumi, A AU - Reed-Gitomer, B AU - Kelleher, C AU - Bekheirnia, MR AU - Schrier, RW PY - 2008/04// UR - http://view.ncbi.nlm.nih.gov/pubmed/18728845 ER -