Identification of a New Naphthalene and Its Derivatives from the Bulb of Eleutherine americana with Inhibitory Activity on Lipopolysaccharide-Induced Nitric Oxide Production. Export

@article{citeulike:3181836, abstract = {A new naphthoquinone, (-)-3-[2-(acetyloxy)propyl]-2-hydroxy-8-methoxy-1,4-naphthoquinone (1) was isolated from the bulb of Eleutherine americana MERR. et HEYNE (Iridaceae) together with two known compounds, eleutherinol (6) and 1,5-dihydroxy-3-methylanthraquinone (7) which were found in this species for the first time. The other known compounds, (-)-isoeleutherin (2), (+)-eleutherin (3), (-)-hongconin (4), and (+)-dihydroeleutherinol (5) which were reported previously from this species, were also isolated in the present study. Compounds 2-6 exhibited potent inhibitory activity on nitric oxide production in RAW 264.7 lipopolysaccharide-activated mouse macrophage cells with IC(50) values of 7.7, 11.4, 19.8, 21.7, and 34.4 muM, respectively, whereas the other two compounds, 1 and 7, were inactive. The structure of compound 1 was elucidated by spectroscopic data analysis including 1D and 2D NMR experiments.}, address = {College of Pharmacy and the Center for Cell Signaling \& Drug Discovery Research, Ewha Womans University.}, author = {Han, Ah-Reum R. and Min, Hye-Young Y. and Nam, Joo-Won W. and Lee, Na-Youn Y. and Wiryawan, Adam and Suprapto, Wahyu and Lee, Sang Kook K. and Lee, Kang Ro R. and Seo, Eun-Kyoung K.}, citeulike-article-id = {3181836}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/18758108}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=18758108}, issn = {0009-2363}, journal = {Chemical \& pharmaceutical bulletin}, keywords = {nitricoxide}, number = {9}, pages = {1314--1316}, posted-at = {2008-09-02 13:17:08}, priority = {2}, title = {Identification of a New Naphthalene and Its Derivatives from the Bulb of Eleutherine americana with Inhibitory Activity on Lipopolysaccharide-Induced Nitric Oxide Production.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18758108}, volume = {56}, year = {2008} }

TY - JOUR ID - citeulike:3181836 L3 - citeulike-article-id:3181836 N2 - A new naphthoquinone, (-)-3-[2-(acetyloxy)propyl]-2-hydroxy-8-methoxy-1,4-naphthoquinone (1) was isolated from the bulb of Eleutherine americana MERR. et HEYNE (Iridaceae) together with two known compounds, eleutherinol (6) and 1,5-dihydroxy-3-methylanthraquinone (7) which were found in this species for the first time. The other known compounds, (-)-isoeleutherin (2), (+)-eleutherin (3), (-)-hongconin (4), and (+)-dihydroeleutherinol (5) which were reported previously from this species, were also isolated in the present study. Compounds 2-6 exhibited potent inhibitory activity on nitric oxide production in RAW 264.7 lipopolysaccharide-activated mouse macrophage cells with IC(50) values of 7.7, 11.4, 19.8, 21.7, and 34.4 muM, respectively, whereas the other two compounds, 1 and 7, were inactive. The structure of compound 1 was elucidated by spectroscopic data analysis including 1D and 2D NMR experiments. IS - 9 JF - Chemical & pharmaceutical bulletin SN - 0009-2363 AD - College of Pharmacy and the Center for Cell Signaling & Drug Discovery Research, Ewha Womans University. EP - 1316 TI - Identification of a New Naphthalene and Its Derivatives from the Bulb of Eleutherine americana with Inhibitory Activity on Lipopolysaccharide-Induced Nitric Oxide Production. VL - 56 SP - 1314 KW - nitricoxide AU - Han, Ah-Reum AU - Min, Hye-Young AU - Nam, Joo-Won AU - Lee, Na-Youn AU - Wiryawan, Adam AU - Suprapto, Wahyu AU - Lee, Sang Kook AU - Lee, Kang Ro AU - Seo, Eun-Kyoung PY - 2008/// UR - http://view.ncbi.nlm.nih.gov/pubmed/18758108 ER -