Liver Repopulation and Carcinogenesis: Two Sides of the Same Coin? Export

@article{citeulike:4182132, abstract = {Liver repopulation by transplanted normal hepatocytes has been described in a number of experimental settings. Extensive repopulation can also occur from the selective proliferation of endogenous normal hepatocytes, both in experimental animals and in the human liver. This review highlights the intriguing association between clinical and experimental conditions related to liver repopulation and an increased risk for development of hepatocellular carcinoma. It is suggested that any microenvironment that is able to sustain the clonal growth of normal transplanted (or endogenous) hepatocytes is also geared to select for the emergence of rare resistant cells with an altered phenotype. Whereas the first pathway leads to liver repopulation with normal histology, the latter results in the growth of focal proliferative lesions and carries an increased risk of neoplastic disease. The implications of this association are discussed, both in terms of pathogenetic significance and possible therapeutic exploitation. 10.2353/ajpath.2008.070910}, author = {Marongiu, Fabio and Doratiotto, Silvia and Montisci, Stefania and Pani, Paolo and Laconi, Ezio}, citeulike-article-id = {4182132}, citeulike-linkout-0 = {http://dx.doi.org/10.2353/ajpath.2008.070910}, citeulike-linkout-1 = {http://ajp.amjpathol.org/cgi/content/abstract/172/4/857}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18321999}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18321999}, day = {1}, doi = {10.2353/ajpath.2008.070910}, issn = {0002-9440}, journal = {Am J Pathol}, keywords = {carcinogenesis, liver, regeneration}, month = {April}, number = {4}, pages = {857--864}, posted-at = {2009-11-11 11:12:58}, priority = {2}, title = {Liver Repopulation and Carcinogenesis: Two Sides of the Same Coin?}, url = {http://dx.doi.org/10.2353/ajpath.2008.070910}, volume = {172}, year = {2008} }

TY - JOUR ID - citeulike:4182132 L3 - citeulike-article-id:4182132 N2 - Liver repopulation by transplanted normal hepatocytes has been described in a number of experimental settings. Extensive repopulation can also occur from the selective proliferation of endogenous normal hepatocytes, both in experimental animals and in the human liver. This review highlights the intriguing association between clinical and experimental conditions related to liver repopulation and an increased risk for development of hepatocellular carcinoma. It is suggested that any microenvironment that is able to sustain the clonal growth of normal transplanted (or endogenous) hepatocytes is also geared to select for the emergence of rare resistant cells with an altered phenotype. Whereas the first pathway leads to liver repopulation with normal histology, the latter results in the growth of focal proliferative lesions and carries an increased risk of neoplastic disease. The implications of this association are discussed, both in terms of pathogenetic significance and possible therapeutic exploitation. 10.2353/ajpath.2008.070910 IS - 4 JF - Am J Pathol SN - 0002-9440 EP - 864 TI - Liver Repopulation and Carcinogenesis: Two Sides of the Same Coin? VL - 172 SP - 857 KW - carcinogenesis KW - liver KW - regeneration AU - Marongiu, Fabio AU - Doratiotto, Silvia AU - Montisci, Stefania AU - Pani, Paolo AU - Laconi, Ezio PY - 2008/04/01/ UR - http://dx.doi.org/10.2353/ajpath.2008.070910 ER -